编码参与水稻白叶枯病菌中黄色单胞菌素生物合成和外膜定位功能的基因座。
Genetic locus encoding functions involved in biosynthesis and outer membrane localization of xanthomonadin in Xanthomonas oryzae pv. oryzae.
作者信息
Goel Ajay Kumar, Rajagopal Lakshmi, Nagesh Narayana, Sonti Ramesh V
机构信息
Centre for Cellular and Molecular Biology, Hyderabad 500 007, Andhra Pradesh, India.
出版信息
J Bacteriol. 2002 Jul;184(13):3539-48. doi: 10.1128/JB.184.13.3539-3548.2002.
Abstract
Xanthomonadins are membrane-bound, brominated, aryl-polyene pigments specific to the genus Xanthomonas. We have characterized a genetic locus (pig) from Xanthomonas oryzae pv. oryzae which contains four open reading frames (ORFs) that are essential for xanthomonadin production. Three of these ORFs are homologous to acyl carrier proteins, dehydratases, and acyl transferases, suggesting a type II polyketide synthase pathway for xanthomonadin biosynthesis. The fourth ORF has no homologue in the database. For the first time, we report that a putative cytoplasmic membrane protein encoded in the pig locus is required for outer membrane localization of xanthomonadin in X. oryzae pv. oryzae. We also report the identification of a novel 145-bp palindromic Xanthomonas repetitive intergenic consensus element that is present in two places in the pig locus. We estimate that more than 100 copies of this element might be present in the genome of X. oryzae pv. oryzae and other xanthomonads.
摘要
黄单胞菌素是一种与细胞膜结合的、含溴的芳基多烯色素，是黄单胞菌属所特有的。我们已经对来自水稻白叶枯病菌的一个基因座（pig）进行了表征，该基因座包含四个对黄单胞菌素产生至关重要的开放阅读框（ORF）。其中三个ORF与酰基载体蛋白、脱水酶和酰基转移酶同源，这表明黄单胞菌素生物合成存在II型聚酮合酶途径。第四个ORF在数据库中没有同源物。我们首次报道，pig基因座中编码的一种假定的细胞质膜蛋白对于水稻白叶枯病菌中黄单胞菌素在外膜的定位是必需的。我们还报道了鉴定出一种新的145 bp回文黄单胞菌重复基因间共有元件，该元件在pig基因座中有两处存在。我们估计，这种元件在水稻白叶枯病菌和其他黄单胞菌的基因组中可能存在100多个拷贝。
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