生物界中的RND转运蛋白。
RND transporters in the living world.
作者信息
Nikaido Hiroshi
机构信息
Department of Molecular and Cell Biology, University of California, Berkeley, CA, 94720, USA.
出版信息
Res Microbiol. 2018 Sep-Oct;169(7-8):363-371. doi: 10.1016/j.resmic.2018.03.001. Epub 2018 Mar 22.
Abstract
Transporters of the RND superfamily are well-known as the major drug efflux pumps of Gram-negative bacteria. However, they are widespread in organisms ranging from Archaea to Eukaryotes, and perform diverse functions. This review gives a brief overview of these diverse members of the superfamily with emphasis on their structure and functions.
摘要
RND超家族转运蛋白是革兰氏阴性菌中主要的药物外排泵，广为人知。然而，它们广泛存在于从古菌到真核生物的各种生物体中，并执行多种功能。本文综述了该超家族的这些不同成员，重点介绍了它们的结构和功能。
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