Hellman L, Fukushima D K, Roffwarg H, Fishman J
J Clin Endocrinol Metab. 1975 Dec;41(06):1014-9. doi: 10.1210/jcem-41-6-1014.
The production rates of estradiol and cortisol in two male opiate addicts while on narcotic maintenance, were in the low normal or subnormal range. There was a sharp several-fold increase upon withdrawal with a subsequent fall to normal values after a period of abstinence. The changes in estradiol production rates were proportionally greater than those of cortisol and suggest that they were due to changes in testicular secretion of the precursor testosterone.
两名接受麻醉品维持治疗的男性阿片类成瘾者体内雌二醇和皮质醇的生成率处于正常低限或低于正常范围。戒断时这两种激素的生成率急剧升高数倍，经过一段时间的禁欲后随后又降至正常值。雌二醇生成率的变化比皮质醇的变化在比例上更大，这表明这些变化是由于睾酮前体的睾丸分泌发生了改变。
