Välimäki M, Pelkonen R, Härkönen M, Ylikahri R
Alcohol Alcohol. 1984;19(3):235-42.
Serum concentrations of iodothyronines, cortisol, prolactin, testosterone and the respective tropic hormones were measured in 32 noncirrhotic male alcoholics, aged 28-51 years, at the end of a long drinking period and subsequently during ethanol withdrawal over 1-2 weeks. Seven men had testicular atrophy. On admission one patient had high values for serum thyroxine (T4) and free thyroxine index (FT4I). A blunted response of serum thyrotropin (TSH) to thyrotropin-releasing hormone (TRH) was found in 9 men. Apart from a blunted TSH-response in one man the abnormalities disappeared during the first week of alcohol abstinence. Simultaneously the mean levels of serum T4, FT4I, triiodothyronine, free triiodothyronine index and reverse triiodothyronine were reduced by 12, 14, 5, 8 and 21%, respectively, and the mean of the maximum TSH-response to TRH was increased by 55%. At the time of stopping drinking two men had high morning values and six an abnormal diurnal rhythm of serum cortisol. High serum ACTH-levels associated with normal serum cortisol concentrations were found in 12 men. During the first week of alcohol abstinence the mean morning values for serum cortisol and ACTH were reduced by 18 and 42%, respectively. The serum ACTH-levels remained high in 6 men but the abnormalities in cortisol secretion disappeared. On admission four men had low serum concentrations of testosterone which were normalized during ethanol withdrawal over one week. At the same time the mean level of serum testosterone was increased by 19%. Mild hyperprolactinaemia found in 7 patients on admission disappeared in 4 men during the first week of ethanol withdrawal.(ABSTRACT TRUNCATED AT 250 WORDS)
在32名年龄在28至51岁之间的非肝硬化男性酗酒者中，在长时间饮酒期结束时以及随后1至2周的乙醇戒断期间，测量了血清甲状腺素、皮质醇、催乳素、睾酮以及各自的促激素水平。7名男性存在睾丸萎缩。入院时，1名患者血清甲状腺素（T4）和游离甲状腺素指数（FT4I）值较高。9名男性血清促甲状腺激素（TSH）对促甲状腺激素释放激素（TRH）的反应迟钝。除1名男性TSH反应迟钝外，这些异常在戒酒第一周内消失。同时，血清T4、FT4I、三碘甲状腺原氨酸、游离三碘甲状腺原氨酸指数和反三碘甲状腺原氨酸的平均水平分别降低了12%、14%、5%、8%和21%，TSH对TRH的最大反应平均值增加了55%。戒酒时，2名男性早晨血清皮质醇值较高，6名男性血清皮质醇昼夜节律异常。12名男性血清促肾上腺皮质激素（ACTH）水平高但血清皮质醇浓度正常。在戒酒第一周，血清皮质醇和ACTH的平均早晨值分别降低了18%和42%。6名男性血清ACTH水平仍高，但皮质醇分泌异常消失。入院时4名男性血清睾酮浓度低，在一周的乙醇戒断期间恢复正常。同时，血清睾酮平均水平增加了19%。7名入院时发现轻度高催乳素血症的患者中，4名男性在戒酒第一周内消失。
