Millband David N, Campbell Leigh, Hardwick Kevin G
Wellcome Trust Centre for Cell Biology, University of Edinburgh, King's Buildings, Mayfield Road, UK EH9 3JR.
Trends Cell Biol. 2002 May;12(5):205-9. doi: 10.1016/s0962-8924(02)02276-6.
The spindle checkpoint coordinates the cell biology of mitosis with cell-cycle progression. It ensures that sister-chromatid separation only takes place when all kinetochores have formed stable bipolar microtubule attachments. Here, we discuss recent advances in our understanding of what activates this checkpoint pathway, the molecular nature of the checkpoint signal and its mode of transmission, and how the checkpoint might be inactivated.
纺锤体检查点将有丝分裂的细胞生物学与细胞周期进程协调起来。它确保姐妹染色单体分离仅在所有动粒都形成稳定的双极微管附着时才会发生。在此，我们讨论了在激活该检查点途径的因素、检查点信号的分子本质及其传递模式，以及检查点如何可能被灭活等方面理解的最新进展。
