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一种使用频域磷光法测量组织中氧分布的方法。

A method for measuring oxygen distributions in tissue using frequency domain phosphorometry.

作者信息

Vinogradov Sergei A, Fernandez-Seara Maria A, Dupan Benjamin W, Wilson David F

机构信息

Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Comp Biochem Physiol A Mol Integr Physiol. 2002 May;132(1):147-52. doi: 10.1016/s1095-6433(01)00541-4.

DOI:10.1016/s1095-6433(01)00541-4
PMID:12062203
Abstract

Phosphorescence lifetime of phosphors dissolved in biological fluids is dependent on the local oxygen concentration. When phosphor is added to the blood in vivo there is a distribution of lifetimes due to the distribution of oxygen concentrations in the blood of the sampled tissue volume. The distribution of oxygen can be assessed non-invasively and in practically real-time using frequency domain time-resolved phosphorometry. Here we describe a multi-frequency system for measurements of oxygen distributions in tissue in vivo.

摘要

溶解在生物流体中的磷光体的磷光寿命取决于局部氧浓度。当将磷光体添加到体内血液中时，由于采样组织体积血液中氧浓度的分布，会出现寿命分布情况。可以使用频域时间分辨磷光测定法以无创且几乎实时的方式评估氧分布。在此，我们描述一种用于测量体内组织中氧分布的多频系统。

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