穿透性角膜移植术后二十年的角膜内皮细胞变化
Corneal endothelial cell changes twenty years after penetrating keratoplasty.
作者信息
Inoue Kenji, Kimura Chikako, Amano Shiro, Oshika Tetsuro, Tsuru Tadahiko
机构信息
Department of Ophthalmology, University of Tokyo, School of Medicine, Tokyo, Japan.
出版信息
Jpn J Ophthalmol. 2002 Mar-Apr;46(2):189-92. doi: 10.1016/s0021-5155(01)00485-3.
PURPOSE
To evaluate retrospectively the corneal endothelium in 15 eyes which showed clear cornea for 20 years or longer after penetrating keratoplasty.
METHODS
The corneal endothelium was investigated in 15 eyes. The causative lesion had been keratoconus in 10 eyes and herpetic keratitis in 5 eyes. At the time of surgery, the patients were aged from 6 to 45 years, average 25.3 +/- 10.4 years. The endothelial cell density was measured 10 and 20 years after surgery by specular microscope. The relation between the rate of endothelial cell density loss and postoperative graft rejection, final visual acuity, causative corneal lesion, age of the patient, and age of the donor was evaluated.
RESULTS
The endothelial cell population per mm(2) averaged 998 +/- 343 ten years after surgery and 852 +/- 245 twenty years after surgery. The rate of endothelial cell density loss thus averaged 12.1% +/- 16.3% during the last 10 years. This rate was independent of postoperative graft rejection, final visual acuity, causative corneal lesion, age of the patient, or age of the donor.
CONCLUSIONS
The corneal endothelial cells become stabilized 10 years after surgery in cases where the grafts remain transparent 20 years after surgery.
目的
回顾性评估穿透性角膜移植术后20年或更长时间角膜保持透明的15只眼的角膜内皮情况。
方法
对15只眼的角膜内皮进行研究。致病病变在10只眼中为圆锥角膜，在5只眼中为疱疹性角膜炎。手术时，患者年龄为6至45岁，平均25.3±10.4岁。术后10年和20年通过镜面显微镜测量内皮细胞密度。评估内皮细胞密度损失率与术后移植排斥反应、最终视力、致病角膜病变、患者年龄和供体年龄之间的关系。
结果
术后10年每平方毫米的内皮细胞数量平均为998±343，术后20年为852±245。因此，在过去10年中内皮细胞密度损失率平均为12.1%±16.3%。该比率与术后移植排斥反应、最终视力、致病角膜病变、患者年龄或供体年龄无关。
结论
在术后20年移植片仍保持透明的病例中，角膜内皮细胞在术后10年变得稳定。
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