Kettesy Beata, Nemeth Gabor, Kemeny-Beke Adam, Berta Andras, Modis Laszlo
Department of Ophthalmology,Medical Health and Science Center, University of Debrecen, Nagyerdeikrt. 98, 4032, Debrecen, Hungary,
Wien Klin Wochenschr. 2014 May;126(9-10):286-90. doi: 10.1007/s00508-014-0524-6. Epub 2014 Apr 4.
Corneal transparency is a useful indicator for corneal function. Our aim was to investigate central corneal endothelial cells and corneal thickness in transplanted corneas at an average of 5.4 years after penetrating keratoplasty
The study involved 68 perforated keratoplasty patients with at least a 1 year follow-up. Post-operatively, the central corneal endothelial layer was observed using a contact specular microscope. Central endothelial cell density, corneal thickness and the coefficient of variation of endothelial size were statistically analysed.
The post-operative follow-up time was ranging from 12 months to 23 years. Endothelial cell density (ECD) was 1,501 ± 249 cell/mm(2). The average cell size was 673.6 ± 98.3 μm(2), and the coefficient of variation of cell size was 0.61 ± 0.11. No difference in ECD was detected between diagnostic groups. Corneal thickness was 0.56 ± 0.06 mm. Correlation between ECD and post-operative time was not significant (r = 0.02; p = 0.85).
Our study concluded that ECD showed a higher rate of decrease after penetrating keratoplasty with no relation to pre-operative diagnosis.
角膜透明度是角膜功能的一项有用指标。我们的目的是研究穿透性角膜移植术后平均5.4年时移植角膜的中央角膜内皮细胞和角膜厚度。
本研究纳入了68例穿透性角膜移植患者，且至少随访1年。术后，使用接触式角膜内皮显微镜观察中央角膜内皮细胞层。对中央内皮细胞密度、角膜厚度和内皮细胞大小变异系数进行统计学分析。
术后随访时间为12个月至23年。内皮细胞密度（ECD）为1501±249个细胞/mm²。平均细胞大小为673.6±98.3μm²，细胞大小变异系数为0.61±0.11。各诊断组之间未检测到ECD有差异。角膜厚度为0.56±0.06mm。ECD与术后时间之间的相关性不显著（r = 0.02；p = 0.85）。
我们的研究得出结论，穿透性角膜移植术后ECD下降率较高，且与术前诊断无关。
