穿透性角膜移植术和深板层角膜移植术后内皮细胞密度的变化。
Changes in endothelial cell density following penetrating keratoplasty and deep anterior lamellar keratoplasty.
作者信息
Acar Banu Torun, Vural Ece Turan, Acar Suphi
机构信息
Ophthalmology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, Turkey.
出版信息
Int J Ophthalmol. 2011;4(6):644-7. doi: 10.3980/j.issn.2222-3959.2011.06.14. Epub 2011 Dec 18.
Abstract
AIM
To compare the corneal endothelial cell density (ECD) of clear grafts after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK).
METHODS
The study included 44 and 54 patients treated with PK and DALK, respectively, between March 2006 and April 2010. Corneal ECD was examined using specular microscopy at postoperative 1, 3, 6, 12, and 18 months, and the values were compared.
RESULTS
Corneal ECD reduction in the PK group was 7.4%, 15.2%, 23.5%, and 28.9% at 3, 6, 12 and 18 months respectively after surgery, compared with 4.2 % in the first month (P<0.01). These figures were 3.0%, 6.7%, 7.2%, and 7.7% at 3, 6, 12 and 18 months respectively, compared with 2.2 % in the first month in the DALK group (P>0.05).
CONCLUSION
Compared with DALK, PK significantly reduced ECD of the clear grafts. These results suggest that survival of endothelial cells in grafts is better after DALK than after PK.
摘要
目的
比较穿透性角膜移植术（PK）和深前板层角膜移植术（DALK）后透明植片的角膜内皮细胞密度（ECD）。
方法
该研究纳入了2006年3月至2010年4月期间分别接受PK和DALK治疗的44例和54例患者。术后1、3、6、12和18个月使用角膜内皮显微镜检查角膜ECD，并比较其数值。
结果
PK组术后3、6、12和18个月角膜ECD分别降低7.4%、15.2%、23.5%和28.9%，而术后第1个月降低4.2%（P<0.01）。DALK组术后3、6、12和18个月分别降低3.0%、6.7%、7.2%和7.7%，术后第1个月降低2.2%（P>0.05）。
结论
与DALK相比，PK显著降低了透明植片的ECD。这些结果表明，DALK术后植片内皮细胞的存活率高于PK术后。
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