Hamberger Lars, Hazekamp Johan
Department of Obstetrics and Gynecology, University of Göteborg, Sahlgrenska University Hospital, 45 Goteborg SE413, Sweden.
J Reprod Immunol. 2002 May-Jun;55(1-2):141-8. doi: 10.1016/s0165-0378(01)00135-8.
Assisted reproductive technologies have, during the last two decades, managed to overcome a majority of the reasons for infertility in both women and men. Also, infertility associated to a specific couple can generally be successfully treated. The techniques have been proven both safe and cost effective. There is, however, one major shortcoming: an adverse effect in terms of multiple pregnancy, sometimes in the high order. The present communication gives suggestions on how to avoid multiple pregnancy by correct application and improvement of techniques already utilized today. Controlled ovarian hyperstimulation, fertilization and culture procedures, preimplantation genetic diagnosis, freezing procedures and prolonged embryo culture are all techniques and applications which need improvement if the goal of a predominance for singletons with only occasional twins should be reached within a predictable future.
在过去二十年中，辅助生殖技术已成功克服了导致男女不孕的大部分原因。而且，与特定夫妇相关的不孕症通常也能得到成功治疗。这些技术已被证明既安全又具有成本效益。然而，存在一个主要缺点：多胎妊娠方面的不良影响，有时是高阶多胎妊娠。本通讯就如何通过正确应用和改进目前已使用的技术来避免多胎妊娠给出了建议。如果要在可预见的未来实现以单胎为主、偶尔有双胞胎的目标，那么控制性卵巢过度刺激、受精和培养程序、植入前基因诊断、冷冻程序以及延长胚胎培养等所有技术和应用都需要改进。
