Sugiyama Rikikazu, Nakagawa Koji, Nishi Yayoi, Sugiyama Rie, Ezaki Kei, Inoue Masato
Division of Reproductive Medicine Sugiyama Clinic 1-53-1, Ohara, Setagaya 156-0041 Tokyo Japan.
Reprod Med Biol. 2008 Dec 26;8(1):33-37. doi: 10.1007/s12522-008-0006-5. eCollection 2009 Mar.
The aim of this study was to identify the factors that contribute to the decision to choose single embryo transfer (SET).
Two hundred and nine patients who underwent ART treatment in our clinics between April 2006 and May 2007 were enrolled in this study. All patients had elected to undergo SET before the start of each treatment cycle; a questionnaire was administered to all patients prior to the SET procedure.
The mean age of the patients was 34.6 years old (range: 24-45 years). The mean number of redundant embryos was 3.7 (range: 1-17), and the pregnancy rate per embryo transfer was 25.7%. A total of 121 patients (57.9%) who underwent SET returned their questionnaires. Based on the results of questionnaire, 56.2% of patients who received SET waived their right to choose between single and double embryo transfer. Among patients who selected SET, 67.6% believed that the pregnancy rate resulting from double embryo transfer (DET) is significantly greater than that associated with SET, and 25% of patients wanted to have twins. The majority of patients (80.9%) who underwent SET understood that multi-fetal pregnancy increases the risk of complications during gestation and delivery. Among all patients who completed the questionnaire, 72.8% believed that the number of transferred embryos should not be controlled by law.
The results of the present study show that greater than one-half of patients who underwent SET were faced with a dilemma--the difficult choice between their own desires and their clinician's recommendation.
本研究旨在确定促使选择单胚胎移植(SET)的因素。
选取2006年4月至2007年5月期间在我们诊所接受辅助生殖技术(ART)治疗的209例患者纳入本研究。所有患者在每个治疗周期开始前均选择接受单胚胎移植;在进行单胚胎移植手术前,对所有患者进行问卷调查。
患者的平均年龄为34.6岁(范围:24 - 45岁)。多余胚胎的平均数量为3.7个(范围:1 - 17个),每次胚胎移植的妊娠率为25.7%。共有121例接受单胚胎移植的患者(57.9%)返回了问卷。根据问卷调查结果,接受单胚胎移植的患者中有56.2%放弃了在单胚胎移植和双胚胎移植之间进行选择的权利。在选择单胚胎移植的患者中,67.6%认为双胚胎移植(DET)的妊娠率明显高于单胚胎移植,25%的患者想要双胞胎。接受单胚胎移植的大多数患者(80.9%)明白多胎妊娠会增加妊娠和分娩期间并发症的风险。在所有完成问卷的患者中,72.8%认为移植胚胎的数量不应受法律控制。
本研究结果表明,接受单胚胎移植的患者中有超过一半面临两难境地——在自身愿望和临床医生建议之间艰难抉择。