Cook Ian A, Leuchter Andrew F, Morgan Melinda, Witte Elise, Stubbeman William F, Abrams Michelle, Rosenberg Susan, Uijtdehaage Sebastian H J
Quantitative EEG Laboratory, Neuropsychiatric Institute and Hospital, UCLA School of Medicine, University of California, 760 Westwood Plaza, Los Angeles, CA 90024-1759, USA.
Neuropsychopharmacology. 2002 Jul;27(1):120-31. doi: 10.1016/S0893-133X(02)00294-4.
Previous studies have shown that changes in brain function precede clinical response to antidepressant medications. Here we examined quantitative EEG (QEEG) absolute and relative power and a new measure, cordance, for detecting regional changes associated with treatment response. Fifty-one adults with unipolar depression completed treatment trials using either fluoxetine or venlafaxine vs. placebo. Data were recorded at baseline and after 48 h and 1 week on drug or placebo. Baseline and change from baseline values were examined for specific brain regions in four subject groups (medication and placebo responders and nonresponders). No regional baseline QEEG differences were found among the groups; there also were no significant changes in theta power over time. In contrast, medication responders uniquely showed significant decreases in prefrontal cordance at 48 h and 1 week. Clinical differences did not emerge until after four weeks. Subjects with greater changes in cordance had the most complete 8-week responses. These findings implicate the prefrontal region in mediating response to antidepressant medications. Cordance may have clinical applicability as a leading indicator of individual response.
先前的研究表明，大脑功能的变化先于对抗抑郁药物的临床反应。在此，我们检测了定量脑电图（QEEG）的绝对功率和相对功率以及一种新指标——协调性，以检测与治疗反应相关的区域变化。51名单相抑郁症成年人完成了使用氟西汀或文拉法辛与安慰剂对照的治疗试验。在基线以及用药或安慰剂治疗48小时和1周后记录数据。在四个受试者组（药物治疗反应者、安慰剂治疗反应者和无反应者）中，对特定脑区的基线值和相对于基线值的变化进行了检测。各组之间未发现区域基线QEEG差异；随着时间推移，θ波功率也无显著变化。相比之下，药物治疗反应者在48小时和1周时前额叶协调性独特地显著降低。临床差异直到四周后才出现。协调性变化更大的受试者在8周时反应最完全。这些发现表明前额叶区域在介导对抗抑郁药物的反应中起作用。协调性可能作为个体反应的领先指标具有临床应用价值。
