Lemke I, Rogalla P, Bullerdiek J
Center of Human Genetics, University of Bremen, Bremen, Germany.
Cytogenet Cell Genet. 2001;95(3-4):153-6. doi: 10.1159/000059338.
The lipoma preferred partner (LPP) gene is fused to the high mobility group protein gene HMGIC in lipomas and pulmonary chondroid hamartomas. In addition, a fusion of LPP to the mixed lineage leukemia (MLL) gene has been described in a case of acute myeloid leukemia. Herein, a novel LPP fusion transcript of LPP in a lipoma is described that points to the possible oncogenic potential of LPP.
脂肪瘤优先伙伴（LPP）基因在脂肪瘤和肺软骨样错构瘤中与高迁移率族蛋白基因HMGIC融合。此外，在1例急性髓系白血病中已报道LPP与混合谱系白血病（MLL）基因融合。在此，描述了脂肪瘤中一种新的LPP融合转录本，提示LPP可能具有致癌潜能。
