Department of Pediatrics, Klinikum rechts der Isar, Technische Universität München, Pediatric Oncology Center, Kölner Platz 1, D-80804 Munich, Germany.
Transl Oncol. 2009 Aug 18;2(3):107-16. doi: 10.1593/tlo.09112.
Integrating signals from the extracellular matrix through the cell surface into the nucleus is an essential feature of metazoan life. To date, many signal transducers known as shuttle proteins have been identified to act as both a cytoskeletal and a signaling protein. Among them, the most prominent representatives are zyxin and lipoma preferred (translocation) partner (LPP). These proteins belong to the LIM domain protein family and are associated with cell migration, proliferation, and transcription. LPP was first identified in benign human lipomas and was subsequently found to be overexpressed in human malignancies such as lung carcinoma, soft tissue sarcoma, and leukemia. This review portrays LPP in the context of human neoplasia based on a study of the literature to define its important role as a novel protooncogene in carcinogenesis.
将细胞外基质的信号通过细胞表面整合到细胞核中是后生动物生命的一个基本特征。迄今为止，已经发现许多被称为穿梭蛋白的信号转导蛋白既能作为细胞骨架蛋白，也能作为信号蛋白发挥作用。其中，最突出的代表是zyxin 和脂肪优先（易位）伙伴（LPP）。这些蛋白质属于 LIM 结构域蛋白家族，与细胞迁移、增殖和转录有关。LPP 最初在良性人类脂肪瘤中被发现，随后在肺癌、软组织肉瘤和白血病等人类恶性肿瘤中被发现过度表达。本综述根据文献研究，将 LPP 置于人类肿瘤发生的背景下，以确定其作为致癌作用中新的原癌基因的重要作用。
