Khan Mahmud Tareq Hassan, Lampronti Ilaria, Martello Dino, Bianchi Nicoletta, Jabbar Shaila, Choudhuri Mohammad Shahabuddin Kabir, Datta Bidduyt Kanti, Gambari Roberto
Pharmacology Research Laboratory, Faculty of Pharmaceutical Sciences, University Science and Technology Chittagong, Bangladesh.
Int J Oncol. 2002 Jul;21(1):187-92.
In this study we compared the in vitro antiproliferative activity of extracts from medicinal plants toward human tumor cell lines, including human erythromyeloid K562, B-lymphoid Raji, T-lymphoid Jurkat, erythroleukemic HEL cell lines. Extracts from Emblica officinalis were the most active in inhibiting in vitro cell proliferation, after comparison to those from Terminalia arjuna, Aphanamixis polystachya, Oroxylum indicum, Cuscuta reflexa, Aegle marmelos, Saraca asoka, Rumex maritimus, Lagerstroemia speciosa, Red Sandalwood. Emblica officinalis extracts have been studied previously, due to their hepatoprotective, antioxidant, antifungal, antimicrobial and anti-inflammatory medicinal activities. Gas chromatography/mass spectrometry analyses allowed to identify pyrogallol as the common compound present both in unfractionated and n-butanol fraction of Emblica officinalis extracts. Antiproliferative effects of pyrogallol were therefore determined on human tumor cell lines thus identifying pyrogallol as an active component of Emblica officinalis extracts.
在本研究中，我们比较了药用植物提取物对人肿瘤细胞系的体外抗增殖活性，这些细胞系包括人红髓样K562、B淋巴细胞Raji、T淋巴细胞Jurkat、红白血病HEL细胞系。与余甘子、诃子、多穗阿芳榄仁、木蝴蝶、菟丝子、木苹果、无忧花、海滨酸模、紫薇、降香檀的提取物相比，余甘子提取物在抑制体外细胞增殖方面活性最强。余甘子提取物此前已因其保肝、抗氧化、抗真菌、抗菌和抗炎药用活性而得到研究。气相色谱/质谱分析能够鉴定出连苯三酚是余甘子提取物的未分级提取物和正丁醇馏分中均存在的共同化合物。因此，测定了连苯三酚对人肿瘤细胞系的抗增殖作用，从而确定连苯三酚是余甘子提取物的一种活性成分。
