Dobritz M, Radkow T, Nittka M, Bautz W, Fellner F A
Institut für Diagnostische Radiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
Rofo. 2002 Jun;174(6):738-41. doi: 10.1055/s-2002-32223.
The VIBE (volume interpolated breath-hold examination) sequence in combination with parallel acquisition technique (iPAT: integrated parallel acquisition technique) allows dynamic contrast-enhanced MRI of the liver with high temporal and spatial resolution. The aim of this study was to obtain first clinical experience with this technique for the detection and characterization of focal liver lesions.
We examined 10 consecutive patients using a 1.5 T MR system (gradient field strength 30 mT/m) with a phased-array coil combination. Following sequences were acquired: T 2 -w TSE and T 1 -w FLASH, after administration of gadolinium, 6 VIBE sequences with iPAT (TR/TE/matrix/partition thickness/time of acquisition: 6.2 ms/ 3.2 ms/256 x 192/4 mm/13 s), as well as T 1 -weighted FLASH with fat saturation. Two observers evaluated the different sequences concerning the number of lesions and their dignity. Following lesions were found: hepatocellular carcinoma (5 patients), hemangioma (2), metastasis (1), cyst (1), adenoma (1).
The VIBE sequences were superior for the detection of lesions with arterial hyperperfusion with a total of 33 focal lesions. 21 lesions were found with T 2 -w TSE and 20 with plain T 1 -weighted FLASH. Diagnostic accuracy increased with the VIBE sequence in comparison to the other sequences.
VIBE with iPAT allows MR imaging of the liver with high spatial and temporal resolution providing dynamic contrast-enhanced information about the whole liver. This may lead to improved detection of liver lesions, especially hepatocellular carcinoma.
容积内插屏气检查（VIBE）序列结合并行采集技术（iPAT：集成并行采集技术）可实现具有高时间和空间分辨率的肝脏动态对比增强磁共振成像（MRI）。本研究的目的是获得该技术用于检测和鉴别肝脏局灶性病变的初步临床经验。
我们使用配备相控阵线圈组合的1.5T MR系统（梯度场强30mT/m）对10例连续患者进行了检查。采集了以下序列：钆剂注射后，T2加权快速自旋回波（T2-w TSE）和T1加权快速小角度激发（T1-w FLASH）序列，6个带有iPAT的VIBE序列（重复时间/回波时间/矩阵/层厚/采集时间：6.2毫秒/3.2毫秒/256×192/4毫米/13秒），以及脂肪饱和的T1加权FLASH序列。两名观察者对不同序列的病变数量及其特征进行评估，并发现了以下病变：肝细胞癌（5例）、血管瘤（2例）、转移瘤（1例）、囊肿（1例）、腺瘤（1例）。
VIBE序列在检测动脉期高灌注病变方面表现更优；共发现33个局灶性病变（T2-w TSE序列发现21个，平扫T1加权FLASH序列发现20个）。与其他序列相比VIBE序列的诊断准确性更高。
VIBE序列结合iPAT可实现肝脏的高时空分辨率磁共振成像，并能提供全肝的动态对比增强信息，这可能会改善肝脏病变尤其是肝细胞癌的检测。
