Tanimoto Akihiro, Yuasa Yuji, Jinzaki Masahiro, Nakatsuka Seishi, Takeda Toshiaki, Kurata Tadayoshi, Shinmoto Hiroshi, Kuribayashi Sachio
Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan.
Radiat Med. 2002 Jul-Aug;20(4):169-79.
To qualitatively and quantitatively evaluate the diagnostic efficacy of the breath-hold magnetic resonance (MR) imaging sequences in widespread clinical use for detection and characterization of focal hepatic lesions.
Fifty patients with 143 lesions [57 hepatocellular carcinomas (HCC), 10 borderline lesions, 18 metastatic tumors, 21 hemangiomas, and 37 cysts] underwent single-shot fast spin echo (SSFSE), fast spin echo (FSE), and gadolinium-enhanced dynamic fast spoiled gradient-recalled acquisition in steady state (FSPGR) breath-hold MR imaging of the liver. Alternative free receiver operating characteristic (AFROC) analysis was performed to independently and prospectively assess each sequence.
For solid lesions, dynamic FSPGR allowed the most sensitive lesion detection and produced the highest lesion conspicuity and lesion-liver contrast-to-noise ratio (CNR). For non-solid benign lesions, SSFSE and FSE produced better results than dynamic FSPGR. SSFSE allowed the most sensitive detection and produced the best lesion conspicuity and lesion-liver CNR.
SSFSE and dynamic FSPGR comprise the optimal imaging protocol for breath-hold MR assessment of focal hepatic lesions. This combination of sequences allows acquisition of critical diagnostic information about both inherent T2 and T1 lesion contrast and lesion vascularity.
对广泛应用于临床的屏气磁共振（MR）成像序列检测和鉴别肝脏局灶性病变的诊断效能进行定性和定量评估。
50例患者共143个病变[57个肝细胞癌（HCC）、10个临界病变、18个转移瘤、21个血管瘤和37个囊肿]接受了肝脏的单次激发快速自旋回波（SSFSE）、快速自旋回波（FSE）和钆增强动态快速扰相梯度回波稳态采集（FSPGR）屏气MR成像。采用交替自由响应特性（AFROC）分析对每个序列进行独立的前瞻性评估。
对于实性病变，动态FSPGR对病变的检测最为敏感，病变显示度最高，病变-肝脏对比噪声比（CNR）也最高。对于非实性良性病变，SSFSE和FSE的结果优于动态FSPGR。SSFSE对病变的检测最为敏感，病变显示度最佳，病变-肝脏CNR也最佳。
SSFSE和动态FSPGR构成了屏气MR评估肝脏局灶性病变的最佳成像方案。这种序列组合能够获取有关病变固有T2和T1对比以及病变血管性的关键诊断信息。
