Salles Gilles
Service d'hématologie Centre hospitalier Lyon-Sud, 69495 Pierre-Bénite.
Rev Prat. 2002 May 1;52(9):966-71.
Chronic lymphoproliferative disorders include several entities that share an initial indolent presentation but are considered at present not to be curable. Follicular lymphoma are more frequent and well characterized; therapeutic recommendations are adapted to prognostic factors such as stage and tumour mass. Marginal zone lymphoma were more recently described and include extranodal MALT lymphomas as well as splenic, leukemic or nodal lymphomas, each with its own clinical features. Lymphocytic lymphomas resemble to chronic lymphocytic leukemia and can be treated in the same way, while mantle cell lymphomas have a very poor outcome. A better definition of these entities should allow to clarify therapeutic recommendations before more efficient treatments become available.
慢性淋巴细胞增殖性疾病包括几种起初表现为惰性但目前被认为无法治愈的疾病。滤泡性淋巴瘤更为常见且特征明确;治疗建议根据分期和肿瘤大小等预后因素进行调整。边缘区淋巴瘤是最近才被描述的,包括结外黏膜相关淋巴组织淋巴瘤以及脾、白血病性或淋巴结淋巴瘤,每种都有其自身的临床特征。淋巴细胞淋巴瘤类似于慢性淋巴细胞白血病,可采用相同的治疗方法,而套细胞淋巴瘤的预后很差。对这些疾病的更好定义应有助于在更有效的治疗方法出现之前明确治疗建议。