[Aggressive lymphomas].

Treatment strategies of aggressive lymphoma are the subject of this review. Main regimens of chemotherapy are described, as well as prognostic factors that direct therapeutic decisions. First-line treatment modalities of localized and advanced disease are envisaged, including the role of high-dose therapy with hematopoietic support, as well as salvage treatment of failures. Finally, the recent and major impact of immunotherapy based on the CD20 monoclonal antibody is outlined.