Haioun Corinne, Reyes Félix
Service d'hématologie clinique Hôpital Henri-Mondor, 94010 Créteil.
Rev Prat. 2002 May 1;52(9):972-7.
Treatment strategies of aggressive lymphoma are the subject of this review. Main regimens of chemotherapy are described, as well as prognostic factors that direct therapeutic decisions. First-line treatment modalities of localized and advanced disease are envisaged, including the role of high-dose therapy with hematopoietic support, as well as salvage treatment of failures. Finally, the recent and major impact of immunotherapy based on the CD20 monoclonal antibody is outlined.
侵袭性淋巴瘤的治疗策略是本综述的主题。文中描述了主要的化疗方案以及指导治疗决策的预后因素。探讨了局限性和晚期疾病的一线治疗方式，包括造血支持下的高剂量治疗的作用以及对治疗失败后的挽救治疗。最后，概述了基于CD20单克隆抗体的免疫疗法的近期重大影响。
