Yuen Sonia J Ahn, Rubin Peter A D
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Ophthalmol Clin North Am. 2002 Mar;15(1):121-6. doi: 10.1016/s0896-1549(01)00003-7.
Pathogenesis of idiopathic orbital inflammation remains elusive but several lines of evidence point to immune-mediated processes as the likely underlying ocular mechanism. The exact nature of the immunological process and possible role of infection need to be elucidated in greater depth. There is an obvious need for a more satisfactory animal model for orbital pseudotumor. Given the prevalence of recurrent and persistent orbital inflammation, therapeutic alternatives to corticosteroids need to be further explored and systematically investigated.
特发性眼眶炎症的发病机制仍不明确，但有几条证据表明免疫介导过程可能是潜在的眼部机制。免疫过程的确切性质以及感染可能发挥的作用需要更深入地阐明。显然需要一种更理想的眼眶假瘤动物模型。鉴于复发性和持续性眼眶炎症的普遍性，需要进一步探索并系统研究皮质类固醇之外的治疗选择。
