Borboli Sheila, Colby Kathryn
Department Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Ophthalmol Clin North Am. 2002 Mar;15(1):17-25. doi: 10.1016/s0896-1549(01)00016-5.
Fuchs' endothelial dystrophy is a common disease that has been widely studied since its initial report in 1910 by Ernst Fuchs. Although its clinical course and pathologic characteristics are well described, the etiology and inheritance pattern are still ambiguous. Ongoing work is evaluating the role of mitochondrial DNA in the pathogenesis of FED. Significant advances in the surgical treatment of FED, in part utilizing some of the techniques of refractive surgery, are promising thus far. Larger case series are needed to fully assess the safety, efficacy and indications of these techniques. Indeed, the time is right to take "a fresh look at an aging disease" [9].
富克斯角膜内皮营养不良是一种常见疾病，自1910年恩斯特·富克斯首次报告以来，已得到广泛研究。尽管其临床病程和病理特征已有详细描述，但其病因和遗传模式仍不明确。目前正在评估线粒体DNA在富克斯角膜内皮营养不良发病机制中的作用。富克斯角膜内皮营养不良手术治疗方面取得了重大进展，部分采用了一些屈光手术技术，迄今为止前景良好。需要更大规模的病例系列研究来全面评估这些技术的安全性、有效性和适应证。事实上，现在正是“重新审视一种老年疾病”的恰当时机[9]。
