Wilson S E, Bourne W M
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota 55905.
Cornea. 1988;7(1):2-18.
Fuchs' dystrophy is an inherited disorder of unknown etiology in which the corneal endothelial cells develop morphologic and functional abnormalities. Clinically, the disease progresses slowly over a period of 20 or more years from asymptomatic cornea guttata to corneal edema with decreased vision and pain. Pathologic studies suggest abnormalities in endothelial function occurring early in life, although symptoms usually do not appear until middle age. The definitive treatment for Fuchs' dystrophy is penetrating keratoplasty. Recent findings regarding the pathophysiology of the disease have increased our understanding of it and have suggested areas for future research.
富克斯角膜内皮营养不良是一种病因不明的遗传性疾病，其中角膜内皮细胞会出现形态和功能异常。临床上，该疾病从无症状的角膜小滴发展到角膜水肿、视力下降和疼痛，会在20年或更长时间内缓慢进展。病理研究表明，内皮功能异常在生命早期就已出现，尽管症状通常直到中年才会显现。富克斯角膜内皮营养不良的 definitive 治疗方法是穿透性角膜移植术。关于该疾病病理生理学的最新研究结果增进了我们对它的理解，并提出了未来研究的方向。 （注：原文中“definitive”此处翻译为“决定性的”较合适，但结合语境“治疗方法”，用“确定的、明确的”来理解更通顺，整体意思是明确的治疗方法即穿透性角膜移植术 ）
