Balon Norbert, Kriem Badreddine, Weiss Michel, Rostain Jean-Claude
Université de la Méditerranée et IMNSSA, E.A. 3280, Laboratoire de Physiopathologie et Action Thérapeutique des Gaz sous Pression, Faculté de Médecine Nord, IFR Jean Roche, Marseille, France.
Neurochem Res. 2002 May;27(5):373-9. doi: 10.1023/a:1015595729411.
The nigral GABAergic regulation of striatal dopamine release was investigated using voltammetry in freely moving rats. The local administration of muscimol (1 nM) in the substantia nigra pars compacta, but not in the substantia nigra pars reticulata, increased the striatal dopamine release. In contrast, the administration of baclofen (10 nM) in the substantia nigra pars reticulata, but not in the substantia nigra pars compacta, produced a decrease of the striatal dopamine release. Opposite effects were respectively observed after administration of GABA(A) and GABA(B) antagonists. These data lead us to suggest a differential presynaptic GABAergic control of the dopaminergic neurotransmission through GABA(A) receptors in the substantia nigra pars compacta, and GABA(B) receptors in the substantia nigra pars reticulata.
利用伏安法在自由活动的大鼠中研究黑质对纹状体多巴胺释放的γ-氨基丁酸能调节。在黑质致密部局部注射蝇蕈醇（1纳摩尔）可增加纹状体多巴胺释放，但在黑质网状部注射则无此作用。相反，在黑质网状部注射巴氯芬（10纳摩尔）可使纹状体多巴胺释放减少，而在黑质致密部注射则无此作用。给予γ-氨基丁酸A和γ-氨基丁酸B拮抗剂后分别观察到相反的效应。这些数据使我们提出，通过黑质致密部的γ-氨基丁酸A受体和黑质网状部的γ-氨基丁酸B受体，对多巴胺能神经传递存在不同的突触前γ-氨基丁酸能控制。
