Ford Michael J, Tetler Lee W, White John, Rimmer Duncan
Division of Chemistry, School of Science and Mathematics, Sheffield Hallam University, UK.
J Chromatogr A. 2002 Apr 5;952(1-2):165-72. doi: 10.1016/s0021-9673(02)00082-1.
A new method for the simultaneous qualitative and quantitative determination of alkyl benzyl and dialkyl quaternary ammonium compounds (QACs) has been developed. Analysis is by reversed-phase high-performance liquid chromatography coupled with electrospray ionisation mass spectrometry. QACs are extremely amenable to the electrospray ionisation technique (limit of detection of BAC C12 homologue 3 ng ml(-1)). The selectivity of mass spectrometric detection allows simultaneous determination of benzyl and dialkyl dimethyl ammonium compounds. The method was successfully applied to the analysis of real samples (occupational hygiene sampling devices, products and swimming pool water). Structural information was obtained by MS-MS and cone voltage ion dissociation techniques. Ion dissociation enabled the structural elucidation of an unknown quaternary ammonium compound present in a commercial formulation.
已开发出一种同时定性和定量测定烷基苄基和二烷基季铵化合物（QACs）的新方法。通过反相高效液相色谱与电喷雾电离质谱联用进行分析。QACs非常适合电喷雾电离技术（BAC C12同系物的检测限为3 ng ml(-1)）。质谱检测的选择性允许同时测定苄基和二烷基二甲基铵化合物。该方法已成功应用于实际样品（职业卫生采样装置、产品和游泳池水）的分析。通过MS-MS和锥电压离子解离技术获得了结构信息。离子解离使得能够阐明商业配方中存在的一种未知季铵化合物的结构。
