Franks Stephen
Department of Reproductive Science and Medicine, Institute of Reproductive and Developmental Biology, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London, W12 0NN, UK.
Best Pract Res Clin Endocrinol Metab. 2002 Jun;16(2):263-72. doi: 10.1053/beem.2002.0203.
Polycystic ovary syndrome (PCOS) frequently presents during adolescence and is the commonest cause of menstrual irregularity and hirsutism. The characteristic endocrine abnormalities include hypersecretion of androgens and LH. Metabolic dysfunction is also a feature of many young women with PCOS. Hyperinsulinaemia and insulin resistance, which can be regarded as an exaggeration of the normal metabolic changes that occur during puberty, are further amplified by obesity. The aetiology of PCOS is uncertain but there is evidence for a primary abnormality of ovarian androgen production which is manifest at puberty but may have its origins in childhood or even during fetal development.
多囊卵巢综合征（PCOS）常在青春期出现，是月经不调和多毛症最常见的原因。其特征性内分泌异常包括雄激素和促黄体生成素（LH）分泌过多。代谢功能障碍也是许多患有PCOS的年轻女性的一个特征。高胰岛素血症和胰岛素抵抗可被视为青春期正常代谢变化的一种夸张表现，而肥胖会进一步加剧这种情况。PCOS的病因尚不确定，但有证据表明卵巢雄激素产生存在原发性异常，这种异常在青春期表现出来，但其起源可能在儿童期甚至胎儿发育期间。
