Drewes Asbjørn Mohr, Schipper Klaus-Peter, Dimcevski Georg, Petersen Poul, Andersen Ole Kaeseler, Gregersen Hans, Arendt-Nielsen Lars
Department of Medical Gastroenterology, Aalborg Hospital 9000, 9000 Aalborg, Denmark.
Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G95-103. doi: 10.1152/ajpgi.00496.2001.
A new multimodal pain assessment model was developed integrating electrical, mechanical, cold, and warmth stimuli into the same device. The device, with a bag and electrodes for electrical stimulation, was positioned in the lower part of the esophagus in 11 healthy subjects. Mechanical stimuli were delivered with an impedance planimetric system. Thermal stimuli were performed by circulating water of different temperatures (5-50 degrees C) inside the bag. All subjects reported both nonpainful and painful local and referred sensations to all stimuli. Temporal summation to repeated electrical stimuli could be studied. For all stimuli, there was a relationship between stimulus intensity and pain intensity. The referred pain area increased with increasing intensity of the electrical and mechanical stimuli. There were several differences between the sensations evoked by the four stimulus modalities, indicating activation of different visceral nerve pathways. This model offers the possibility for controlled multimodal stimuli activating the superficial and deeper layers of the human gut and should be used in basic, clinical, and pharmacological pain studies.
一种新的多模式疼痛评估模型被开发出来，该模型将电、机械、冷和热刺激整合到同一设备中。该设备带有一个袋子和用于电刺激的电极，被放置在11名健康受试者的食管下部。机械刺激通过阻抗平面测量系统进行。热刺激通过在袋子内循环不同温度（5 - 50摄氏度）的水来实现。所有受试者对所有刺激都报告了无痛和疼痛的局部及牵涉感觉。可以研究对重复电刺激的时间总和。对于所有刺激，刺激强度与疼痛强度之间存在关系。牵涉痛区域随着电刺激和机械刺激强度的增加而增大。四种刺激模式所诱发的感觉之间存在若干差异，表明不同内脏神经通路被激活。该模型为激活人体肠道浅层和深层的可控多模式刺激提供了可能性，应在基础、临床和药理学疼痛研究中使用。
