西格玛B有助于单核细胞增生李斯特菌中由PrfA介导的毒力。
Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes.
作者信息
Nadon Celine A, Bowen Barbara M, Wiedmann Martin, Boor Kathryn J
机构信息
Department of Food Science, Cornell University, Ithaca, New York 14853, USA.
出版信息
Infect Immun. 2002 Jul;70(7):3948-52. doi: 10.1128/IAI.70.7.3948-3952.2002.
Abstract
Transcription of the Listeria monocytogenes positive regulatory factor A protein (PrfA) is initiated from either of two promoters immediately upstream of prfA (prfAp(1) and prfAp(2)) or from the upstream plcA promoter. We demonstrate that prfAp(2) is a functional sigma(B)-dependent promoter and that a sigB deletion mutation affects the virulence phenotype of L. monocytogenes. Thus, the alternative sigma factor sigma(B) contributes to virulence in L. monocytogenes.
摘要
单核细胞增生李斯特菌阳性调节因子A蛋白（PrfA）的转录起始于prfA上游紧邻的两个启动子之一（prfAp(1)和prfAp(2)），或者起始于上游的plcA启动子。我们证明prfAp(2)是一个功能性的依赖于σ(B)的启动子，并且σ(B)缺失突变会影响单核细胞增生李斯特菌的毒力表型。因此，替代的σ因子σ(B)有助于单核细胞增生李斯特菌的毒力。
相似文献
1
Sigma B contributes to PrfA-mediated virulence in Listeria monocytogenes.西格玛B有助于单核细胞增生李斯特菌中由PrfA介导的毒力。
Infect Immun. 2002 Jul;70(7):3948-52. doi: 10.1128/IAI.70.7.3948-3952.2002.
2
SigB-dependent in vitro transcription of prfA and some newly identified genes of Listeria monocytogenes whose expression is affected by PrfA in vivo.西格B依赖的单核细胞增生李斯特菌prfA及一些新鉴定出的基因的体外转录，这些基因的表达在体内受PrfA影响。
J Bacteriol. 2005 Jan;187(2):800-4. doi: 10.1128/JB.187.2.800-804.2005.
3
Listeria monocytogenes sigmaB modulates PrfA-mediated virulence factor expression.单核细胞增生李斯特菌的σB调节PrfA介导的毒力因子表达。
Infect Immun. 2009 May;77(5):2113-24. doi: 10.1128/IAI.01205-08. Epub 2009 Mar 2.
4
The Listeria monocytogenes prfAP2 promoter is regulated by sigma B in a growth phase dependent manner.单核细胞增生李斯特菌的prfAP2启动子受σB以生长阶段依赖性方式调控。
FEMS Microbiol Lett. 2005 Apr 15;245(2):329-36. doi: 10.1016/j.femsle.2005.03.025.
5
Differential activation of virulence gene expression by PrfA, the Listeria monocytogenes virulence regulator.单核细胞增生李斯特菌毒力调节因子PrfA对毒力基因表达的差异激活
J Bacteriol. 1995 Nov;177(22):6469-76. doi: 10.1128/jb.177.22.6469-6476.1995.
6
Contributions of Listeria monocytogenes sigmaB and PrfA to expression of virulence and stress response genes during extra- and intracellular growth.单核细胞增生李斯特菌的σB和PrfA在胞外和胞内生长过程中对毒力和应激反应基因表达的作用。
Microbiology (Reading). 2006 Jun;152(Pt 6):1827-1838. doi: 10.1099/mic.0.28758-0.
7
PrfA, the transcriptional activator of virulence genes, is upregulated during interaction of Listeria monocytogenes with mammalian cells and in eukaryotic cell extracts.毒力基因转录激活因子PrfA在单核细胞增生李斯特菌与哺乳动物细胞相互作用期间以及在真核细胞提取物中表达上调。
Mol Microbiol. 1999 Nov;34(3):552-61. doi: 10.1046/j.1365-2958.1999.01621.x.
8
Regulation of the prfA transcriptional activator of Listeria monocytogenes: multiple promoter elements contribute to intracellular growth and cell-to-cell spread.单核细胞增生李斯特菌prfA转录激活因子的调控：多个启动子元件有助于细胞内生长和细胞间传播。
Infect Immun. 1993 Jun;61(6):2537-44. doi: 10.1128/iai.61.6.2537-2544.1993.
9
Negative regulation of PrfA, the key activator of Listeria monocytogenes virulence gene expression, is dispensable for bacterial pathogenesis.单核细胞增生李斯特菌毒力基因表达的关键激活因子PrfA的负调控对细菌致病作用而言并非必需。
Microbiology (Reading). 2003 Jan;149(Pt 1):111-20. doi: 10.1099/mic.0.25692-0.
10
SigmaB- and PrfA-dependent transcription of genes previously classified as putative constituents of the Listeria monocytogenes PrfA regulon.先前被归类为单核细胞增生李斯特菌PrfA调控子假定成分的基因的SigmaB和PrfA依赖性转录。
Foodborne Pathog Dis. 2008 Jun;5(3):281-93. doi: 10.1089/fpd.2008.0079.
引用本文的文献
1
Stress-dependent activation of the virulence program ensures bacterial resilience during infection.毒力程序的应激依赖性激活确保细菌在感染期间的恢复力。
mBio. 2025 Jun 11;16(6):e0071925. doi: 10.1128/mbio.00719-25. Epub 2025 Apr 30.
2
Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes.差异应激反应决定了单核细胞增生李斯特菌的种内毒力异质性和宿主适应性。
Nat Microbiol. 2024 Dec;9(12):3345-3361. doi: 10.1038/s41564-024-01859-8. Epub 2024 Nov 22.
3
The PrfA regulon of is induced by growth in low-oxygen microaerophilic conditions.是由低氧微需氧条件下的生长诱导的 PrfA 调控子。
Microbiology (Reading). 2024 Nov;170(11). doi: 10.1099/mic.0.001516.
4
Survival strategies of to environmental hostile stress: biofilm formation and stress responses.应对环境不利应激的生存策略：生物膜形成与应激反应。
Food Sci Biotechnol. 2023 Sep 14;32(12):1631-1651. doi: 10.1007/s10068-023-01427-6. eCollection 2023 Oct.
5
Genomic and pathogenicity islands of -overview of selected aspects.基因组与致病岛——部分选定方面概述
Front Mol Biosci. 2023 Jun 14;10:1161486. doi: 10.3389/fmolb.2023.1161486. eCollection 2023.
6
The Virulence and Infectivity of Listeria monocytogenes Are Not Substantially Altered by Elevated SigB Activity.高 SigB 活性不会显著改变李斯特菌单核细胞增生李斯特菌的毒力和感染力。
Infect Immun. 2023 Jun 15;91(6):e0057122. doi: 10.1128/iai.00571-22. Epub 2023 May 1.
7
SigB modulates expression of novel SigB regulon members via Bc1009 in non-stressed and heat-stressed cells revealing its alternative roles in Bacillus cereus.SigB 通过 Bc1009 调节非应激和热应激细胞中新的 SigB 调控因子成员的表达，揭示了其在蜡样芽胞杆菌中的替代作用。
BMC Microbiol. 2023 Feb 10;23(1):37. doi: 10.1186/s12866-023-02783-3.
8
Deciphering the global roles of Cold shock proteins in nutrient metabolism and stress tolerance.解析冷休克蛋白在营养代谢和应激耐受中的全局作用。
Front Microbiol. 2022 Dec 20;13:1057754. doi: 10.3389/fmicb.2022.1057754. eCollection 2022.
9
Human Listeriosis.人李斯特菌病。
Clin Microbiol Rev. 2023 Mar 23;36(1):e0006019. doi: 10.1128/cmr.00060-19. Epub 2022 Dec 8.
10
Different Shades of : Strain, Serotype, and Lineage-Based Variability in Virulence and Stress Tolerance Profiles.不同层面的：基于菌株、血清型和谱系的毒力及应激耐受性差异。
Front Microbiol. 2022 Jan 4;12:792162. doi: 10.3389/fmicb.2021.792162. eCollection 2021.
本文引用的文献
1
Role of sigma(B) in heat, ethanol, acid, and oxidative stress resistance and during carbon starvation in Listeria monocytogenes.σ(B)在单核细胞增生李斯特菌耐热、耐乙醇、耐酸、抗氧化应激以及碳饥饿过程中的作用。
Appl Environ Microbiol. 2001 Oct;67(10):4454-7. doi: 10.1128/AEM.67.10.4454-4457.2001.
2
Development of a competitive index assay to evaluate the virulence of Listeria monocytogenes actA mutants during primary and secondary infection of mice.开发一种竞争指数测定法，以评估单核细胞增生李斯特菌actA突变体在小鼠初次和二次感染期间的毒力。
Infect Immun. 2001 Sep;69(9):5953-7. doi: 10.1128/IAI.69.9.5953-5957.2001.
3
Biofilm formation by Staphylococcus epidermidis depends on functional RsbU, an activator of the sigB operon: differential activation mechanisms due to ethanol and salt stress.表皮葡萄球菌生物膜的形成依赖于功能性RsbU，它是sigB操纵子的激活剂：乙醇和盐胁迫导致的差异激活机制。
J Bacteriol. 2001 Apr;183(8):2624-33. doi: 10.1128/JB.183.8.2624-2633.2001.
4
Role of sigma(B) in adaptation of Listeria monocytogenes to growth at low temperature.σ(B)在单核细胞增生李斯特菌适应低温生长中的作用。
J Bacteriol. 2000 Dec;182(24):7083-7. doi: 10.1128/JB.182.24.7083-7087.2000.
5
Characterization of the sigma(B) regulon in Staphylococcus aureus.金黄色葡萄球菌中σ(B) 调控子的特性分析
J Bacteriol. 2000 Dec;182(24):6983-91. doi: 10.1128/JB.182.24.6983-6991.2000.
6
Characterization of the operon encoding the alternative sigma(B) factor from Bacillus anthracis and its role in virulence.炭疽芽孢杆菌中编码替代σ因子B的操纵子的特性及其在毒力中的作用。
J Bacteriol. 2000 Sep;182(18):5036-45. doi: 10.1128/JB.182.18.5036-5045.2000.
7
Identification of sigma(B)-dependent genes in Bacillus subtilis using a promoter consensus-directed search and oligonucleotide hybridization.利用启动子共有序列定向搜索和寡核苷酸杂交技术鉴定枯草芽孢杆菌中依赖于σ（B）的基因。
J Bacteriol. 1999 Sep;181(18):5718-24. doi: 10.1128/JB.181.18.5718-5724.1999.
8
Isolation and characterization of a sigB deletion mutant of Staphylococcus aureus.金黄色葡萄球菌sigB缺失突变体的分离与鉴定
Infect Immun. 1999 Jul;67(7):3667-9. doi: 10.1128/IAI.67.7.3667-3669.1999.
9
Deletion of the alternative sigma factor sigmaB in Staphylococcus aureus reveals its function as a global regulator of virulence genes.金黄色葡萄球菌中替代σ因子σB的缺失揭示了其作为毒力基因全局调节因子的功能。
J Bacteriol. 1998 Sep;180(18):4814-20. doi: 10.1128/JB.180.18.4814-4820.1998.
10
Identification of the gene encoding the alternative sigma factor sigmaB from Listeria monocytogenes and its role in osmotolerance.单核细胞增生李斯特菌中编码替代σ因子σB的基因的鉴定及其在渗透压耐受性中的作用。
J Bacteriol. 1998 Sep;180(17):4547-54. doi: 10.1128/JB.180.17.4547-4554.1998.
Zotero 插件