对毒力不同的伯克霍尔德菌菌株产生的类似细胞因子反应与免疫小鼠中的部分交叉保护相关。
Analogous cytokine responses to Burkholderia pseudomallei strains contrasting in virulence correlate with partial cross-protection in immunized mice.
作者信息
Ulett Glen C, Ketheesan Natkunam, Clair Timothy W, McElnea Catriona L, Barnes Jodie L, Hirst Robert G
机构信息
Department of Microbiology and Immunology, School of Medicine, James Cook University, Townsville, Queensland, Australia 4811.
出版信息
Infect Immun. 2002 Jul;70(7):3953-8. doi: 10.1128/IAI.70.7.3953-3958.2002.
Abstract
Cytokine mRNA levels were assessed in Burkholderia pseudomallei-susceptible BALB/c mice and B. pseudomallei-resistant C57BL/6 mice following administration of a sublethal dose of less virulent (LV) B. pseudomallei, a candidate immunogen tested for protection against a highly virulent (HV) challenge. Compared on the basis of the bacterial loads, the cytokine patterns induced by HV and LV B. pseudomallei were similar, involving gamma interferon, interleukin-10, and other cytokines. Partial cross-protection between B. pseudomallei strains is shown to be associated with cytokine profiles involving both type 1 and type 2 cytokines.
摘要
在给予亚致死剂量的低毒力（LV）类鼻疽伯克霍尔德菌（一种经测试用于预防高毒力（HV）攻击的候选免疫原）后，评估了对类鼻疽伯克霍尔德菌敏感的BALB/c小鼠和对类鼻疽伯克霍尔德菌有抗性的C57BL/6小鼠体内细胞因子mRNA水平。基于细菌载量进行比较，HV和LV类鼻疽伯克霍尔德菌诱导的细胞因子模式相似，涉及γ干扰素、白细胞介素-10和其他细胞因子。结果表明，类鼻疽伯克霍尔德菌菌株之间的部分交叉保护与涉及1型和2型细胞因子的细胞因子谱有关。
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