Dstl Porton Down, Salisbury, Wiltshire SP4 0JQ, UK.
Vaccine. 2010 Nov 3;28(47):7551-5. doi: 10.1016/j.vaccine.2010.08.058. Epub 2010 Sep 15.
Burkholderia thailandensis is a less virulent close relative of Burkholderia pseudomallei, a CDC category B biothreat agent. We have previously shown that lipopolysaccharide (LPS) extracted from B. pseudomallei can provide protection against a lethal challenge of B. pseudomallei in a mouse model of melioidosis. Sugar analysis on LPS from B. thailandensis strain E264 confirmed that this polysaccharide has a similar structure to LPS from B. pseudomallei. Mice were immunised with LPS from B. thailandensis or B. pseudomallei and challenged with a lethal dose of B. pseudomallei strain K96243. Similar protection levels were observed when either LPS was used as the immunogen. This data suggests that B. thailandensis LPS has the potential to be used as part of a subunit based vaccine against pathogenic B. pseudomallei.
类鼻疽伯克霍尔德菌是一种毒力较弱的类鼻疽伯克霍尔德菌近缘菌，是疾病预防控制中心 B 类生物威胁剂。我们之前已经表明，从鼻疽伯克霍尔德菌中提取的脂多糖（LPS）可以在类鼻疽的小鼠模型中提供针对鼻疽伯克霍尔德菌致死性挑战的保护。对类鼻疽伯克霍尔德菌 E264 菌株 LPS 的糖分析证实，这种多糖与鼻疽伯克霍尔德菌的 LPS 具有相似的结构。用类鼻疽伯克霍尔德菌或类鼻疽伯克霍尔德菌 LPS 免疫小鼠，并用致死剂量的鼻疽伯克霍尔德菌 K96243 进行攻毒。当 LPS 用作免疫原时，观察到相似的保护水平。这些数据表明，类鼻疽伯克霍尔德菌 LPS 有可能被用作针对致病性鼻疽伯克霍尔德菌的亚单位疫苗的一部分。
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