Matsuda Yoshio, Kouno Satoshi, Nakano Hitoo
Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan.
Fetal Diagn Ther. 2002 Jul-Aug;17(4):228-32. doi: 10.1159/000059374.
We investigated to see the effect of antibiotics on interleukin (IL)-6 and IL-8 in cervicovaginal fluid in patients with premature rupture of the membranes.
Cervicovaginal fluid was sampled on admission and before delivery for measurement of IL-6 and IL-8 from 31 patients with less than 35 weeks of gestation. Concentrations of IL-6 and IL-8 were measured by ELISA.
The concentrations of IL-6 in cervicovaginal fluid in patients who were delivered because of clinical chorioamnionitis with antibiotics (n = 6) were significantly higher than in patients who were delivered because of active labor with (n = 14, p = 0.0133) and without antibiotics (n = 11, p = 0.0067). A significant change in the concentrations of IL-6 and IL-8 in cervicovaginal fluid was not observed in patients with and without antibiotics who were delivered because of active labor.
The concentrations of IL-6 and IL-8 in cervicovaginal fluid might be influenced by the presence of clinical chorioamnionitis, but not by antibiotic administration.
我们研究了抗生素对胎膜早破患者宫颈阴道液中白细胞介素（IL）-6和IL-8的影响。
对31例孕周小于35周的患者在入院时和分娩前采集宫颈阴道液，以检测IL-6和IL-8。采用酶联免疫吸附测定法（ELISA）测量IL-6和IL-8的浓度。
因临床绒毛膜羊膜炎使用抗生素分娩的患者（n = 6）宫颈阴道液中IL-6的浓度显著高于因产程活跃使用抗生素（n = 14，p = 0.0133）和未使用抗生素（n = 11，p = 0.0067）分娩的患者。因产程活跃分娩的患者，无论是否使用抗生素，宫颈阴道液中IL-6和IL-8的浓度均未观察到显著变化。
宫颈阴道液中IL-6和IL-8的浓度可能受临床绒毛膜羊膜炎的影响，但不受抗生素使用的影响。
