Tanaka Y, Narahara H, Takai N, Yoshimatsu J, Anai T, Miyakawa I
Department of Obstetrics and Gynecology, Oita Medical University, Hasama, Japan.
Am J Obstet Gynecol. 1998 Sep;179(3 Pt 1):644-9. doi: 10.1016/s0002-9378(98)70058-4.
We investigated the usefulness of cervicovaginal interleukin-1beta and interleukin-8 levels during pregnancy as markers of preterm and term parturition.
Cervicovaginal fluids were obtained from 119 pregnant women at 24 to 41 weeks' gestation. Cytokine concentrations were measured by enzyme-linked immunoassay.
Interleukin-1beta and interleukin-8 concentrations in cervicovaginal fluids obtained from women not in labor increased exponentially as gestational age increased. Interleukin-1beta and interleukin-8 concentrations were significantly correlated. These cytokine concentrations were significantly higher in patients in preterm labor than in patients at preterm not in labor and were significantly higher in women at term in labor than in women at term not in labor. These cytokine levels were significantly correlated with the degree of cervical dilation and tocolytic index.
These findings suggest that cervicovaginal interleukin-1beta and interleukin-8 contribute to term and preterm parturition. Measurement of cervicovaginal concentrations of these cytokines may be clinically useful in patients with threatened premature delivery.
我们研究了孕期宫颈阴道白细胞介素-1β和白细胞介素-8水平作为早产和足月分娩标志物的实用性。
从119名妊娠24至41周的孕妇中获取宫颈阴道液。通过酶联免疫吸附测定法测量细胞因子浓度。
未临产妇女的宫颈阴道液中白细胞介素-1β和白细胞介素-8浓度随孕周增加呈指数增长。白细胞介素-1β和白细胞介素-8浓度显著相关。早产患者的这些细胞因子浓度显著高于未早产患者，足月临产妇女的这些细胞因子浓度显著高于足月未临产妇女。这些细胞因子水平与宫颈扩张程度和宫缩抑制指数显著相关。
这些发现表明宫颈阴道白细胞介素-1β和白细胞介素-8参与足月和早产分娩。测量这些细胞因子在宫颈阴道中的浓度可能对有早产风险的患者具有临床实用价值。
