Yana Ikuo, Seiki Motoharu
Division of Cancer Cell Research, Institute of Medical Science, The University of Tokyo, Japan.
Clin Exp Metastasis. 2002;19(3):209-15. doi: 10.1023/a:1015527220537.
Matrix metalloproteinases (MMPs), a family of zinc-binding endopeptidases, play important roles in cancer proliferation and dissemination, and may be further associated with other diseases. In particular, membrane-type MMPs (MT-MMPs) are crucial for cancer cell invasion. In this report, we summarize the current views on the role of MT-MMPs in cancer dissemination. The regulated and restricted degradation of the extracellular matrix (ECM) surrounding the tumor surface is a trigger event for cell protrusion and invasion. This is thought to be primarily organized by MT-MMPs, since a shift in balance between cell adhesion molecules, ECM and proteolysis at the focal cell surface may result in conditions especially suitable for cancer cells to progress and invade the ECM. To resolve the physiological mechanisms of cancer invasion and migration, molecular milieu surrounding the MT-MMPs expressed on tumor cell surfaces should be further examined for each cell type, which may consequently provide a novel clinical tool to regulate cancer behavior.
基质金属蛋白酶（MMPs）是一类锌结合内肽酶家族，在癌症增殖和扩散中起重要作用，并且可能与其他疾病进一步相关。特别是，膜型基质金属蛋白酶（MT-MMPs）对癌细胞侵袭至关重要。在本报告中，我们总结了目前关于MT-MMPs在癌症扩散中作用的观点。肿瘤表面周围细胞外基质（ECM）的有序和受限降解是细胞突出和侵袭的触发事件。这被认为主要由MT-MMPs组织，因为细胞粘附分子、ECM和焦点细胞表面蛋白水解之间平衡的改变可能导致特别适合癌细胞进展和侵袭ECM的条件。为了解决癌症侵袭和迁移的生理机制，应针对每种细胞类型进一步研究肿瘤细胞表面表达的MT-MMPs周围的分子环境，这可能因此提供一种调节癌症行为的新型临床工具。
