凋亡性细胞死亡对肾损伤的作用。
Contribution of apoptotic cell death to renal injury.
作者信息
Ortiz A, Lorz C, Justo P, Catalán M P, Egido J
机构信息
Unidad de Dialisis, Fundacion Jimenez Diaz, Av Reyes Catolicos 2, 28040 Madrid, Spain.
出版信息
J Cell Mol Med. 2001 Jan-Mar;5(1):18-32. doi: 10.1111/j.1582-4934.2001.tb00135.x.
Abstract
Cell number abnormalities are frequent in renal diseases, and range from the hypercellularity of postinfectious glomerulonephritis to the cell depletion of chronic renal atrophy. Recent research has shown that apoptosis and its regulatory mechanisms contribute to cell number regulation in the kidney. The role of apoptosis ranges from induction to repair and progression of renal injury. Death ligands and receptors, such as TNF and FasL, proapoptotic and antiapoptotic Bcl-2 family members and caspases have all been shown to participate in apoptosis regulation in the course of renal injury. These proteins represent potential therapeutic targets, which should be further explored.
摘要
细胞数量异常在肾脏疾病中很常见，范围从感染后肾小球肾炎的细胞增多到慢性肾萎缩的细胞减少。最近的研究表明，细胞凋亡及其调节机制有助于肾脏中的细胞数量调节。细胞凋亡的作用范围从肾损伤的诱导到修复和进展。死亡配体和受体，如肿瘤坏死因子（TNF）和Fas配体（FasL）、促凋亡和抗凋亡的Bcl-2家族成员以及半胱天冬酶，均已证实在肾损伤过程中参与细胞凋亡调节。这些蛋白质代表了潜在的治疗靶点，应进一步探索。
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本文引用的文献
1
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Science. 2001 Feb 16;291(5507):1279-84. doi: 10.1126/science.291.5507.1279.
2
Life-or-death decisions by the Bcl-2 protein family.Bcl-2蛋白家族的生死抉择。
Trends Biochem Sci. 2001 Jan;26(1):61-6. doi: 10.1016/s0968-0004(00)01740-0.
3
Expression of apoptosis-related genes and proteins in experimental chronic renal scarring.
J Am Soc Nephrol. 2001 Feb;12(2):275-288. doi: 10.1681/ASN.V122275.
4
Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells.多囊蛋白-1是多囊肾病1基因（PKD1）的产物，可诱导MDCK细胞产生抗凋亡能力和自发形成肾小管的能力。
Mol Cell. 2000 Nov;6(5):1267-73. doi: 10.1016/s1097-2765(00)00123-4.
5
Renal cell loss through cell suicide.通过细胞自杀导致的肾细胞损失。
Kidney Int. 2000 Nov;58(5):2235-6. doi: 10.1111/j.1523-1755.2000.00401.x.
6
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis.两个半胱氨酸蛋白酶家族之间的相互作用。钙蛋白酶在凋亡过程中对caspase-12的激活。
J Cell Biol. 2000 Aug 21;150(4):887-94. doi: 10.1083/jcb.150.4.887.
7
Nephrology forum: apoptotic regulatory proteins in renal injury.肾脏病学论坛：肾损伤中的凋亡调节蛋白
Kidney Int. 2000 Jul;58(1):467-85. doi: 10.1046/j.1523-1755.2000.00188.x.
8
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J Am Soc Nephrol. 2000 Jul;11(7):1266-1277. doi: 10.1681/ASN.V1171266.
9
Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2.由Bcl-2控制的内质网与线粒体之间的凋亡串扰。
Oncogene. 2000 May 4;19(19):2286-95. doi: 10.1038/sj.onc.1203592.
10
Expression of apoptosis regulatory proteins in tubular epithelium stressed in culture or following acute renal failure.凋亡调节蛋白在培养中应激的肾小管上皮细胞或急性肾衰竭后的表达。
Kidney Int. 2000 Mar;57(3):969-81. doi: 10.1046/j.1523-1755.2000.00925.x.
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