Department of Cardiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Acta Biomed. 2021 Nov 3;92(5):e2021285. doi: 10.23750/abm.v92i5.9711.
Decoy receptor 3 (DcR3), is a soluble receptor which is thought to have immune modulator or pro-inflammatory effects. Various risk factors have been suggested for the incidence of cardiovascular diseases (CADs) such as an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of DcR3 with anthropometric, angiographic, echocardiographic, and biochemical parameters in patients with acute myocardial infarction.
A total of 90 patients who were candidates for angiography were included in the study and were divided into three groups: 30 patients with acute myocardial infarction (AMI), 30 patients with stable angina pectoris (SAP), and 30 subjects as control group with a history of chest pain but normal angiography. Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects.
Serum DcR3 and interleukin (IL)-6 levels were significantly increased in patients with AMI compared with SAP and control groups (P < 0.05 to P < 0.001). In addition, there was a positive association between serum level of DcR3 and epicardial fat thickness (EFT), Gensini score, creatine kinase (CK)-MB, IL-6, and white blood cell (WBC) count in CAD patients. The results of multivariate linear regression analysis revealed that WBC count and IL-6 levels were independently associated with serum DcR3 levels.
The current study showed an association of DcR3 and IL-6, WBC count, EFT, CK-MB, and Gensini score for the first time in male AMI patients. Increased DcR3 levels in patients with AMI may be involved in the process of atherosclerosis.
诱饵受体 3（DcR3）是一种可溶性受体，被认为具有免疫调节剂或促炎作用。各种危险因素被认为与心血管疾病（CAD）的发生有关，如炎症因子的增加。本研究旨在探讨 DcR3 与急性心肌梗死患者的人体测量、血管造影、超声心动图和生化参数的相关性。
本研究共纳入 90 名接受血管造影的患者，并将其分为三组：30 名急性心肌梗死（AMI）患者、30 名稳定性心绞痛（SAP）患者和 30 名有胸痛但血管造影正常的对照组。所有患者均测量人体测量、血管造影、超声心动图和生化参数。
与 SAP 和对照组相比，AMI 患者的血清 DcR3 和白细胞介素（IL）-6 水平显著升高（P < 0.05 至 P < 0.001）。此外，在 CAD 患者中，血清 DcR3 水平与心外膜脂肪厚度（EFT）、Gensini 评分、肌酸激酶同工酶（CK-MB）、IL-6 和白细胞（WBC）计数呈正相关。多元线性回归分析结果显示，WBC 计数和 IL-6 水平与血清 DcR3 水平独立相关。
本研究首次显示 DcR3 与白细胞计数、IL-6、EFT、CK-MB 和 Gensini 评分在男性 AMI 患者中存在相关性。AMI 患者中 DcR3 水平的升高可能参与了动脉粥样硬化的过程。
