Stambaugh J J, Berning S E, Bulpitt A E, Hollender E S, Narita M, Ashkin D, Peloquin C A
Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA.
Int J Tuberc Lung Dis. 2002 Jun;6(6):503-9. doi: 10.5588/09640569513011.
Two tuberculosis hospitals in the United States.
To determine the population pharmacokinetic (PK) parameters of ofloxacin following multiple oral doses.
A total of 73 patients with tuberculosis (TB) participated in the study. Subjects received multiple doses of ofloxacin as part of their treatment. They also received concurrent medications based on in vitro susceptibility data. Serum samples were collected over 10 h and assayed by a validated high performance liquid chromatography (HPLC) assay. Concentration-time data were analyzed using population methods.
Ofloxacin concentrations increased linearly with increasing oral doses. Delayed absorption was seen at least once in 29% of patients. Ofloxacin elimination decreased with declining renal function and increasing age. Higher daily doses were well tolerated, and appeared to maximize the peak concentration to minimal inhibitory concentration ratio (Cmax:MIC).
Ofloxacin PK parameters were comparable to those previously published for other patient populations. Higher daily doses may offer pharmacodynamic advantages for the treatment of TB.
美国的两家结核病医院。
确定多次口服氧氟沙星后的群体药代动力学（PK）参数。
共有73例结核病（TB）患者参与了该研究。受试者接受多次剂量的氧氟沙星作为其治疗的一部分。他们还根据体外药敏数据接受了联合用药。在10小时内采集血清样本，并通过经过验证的高效液相色谱（HPLC）分析法进行检测。使用群体方法分析浓度-时间数据。
氧氟沙星浓度随口服剂量增加呈线性增加。29%的患者至少出现过一次吸收延迟。氧氟沙星的消除随着肾功能下降和年龄增加而减少。较高的每日剂量耐受性良好，似乎能使峰浓度与最低抑菌浓度之比（Cmax:MIC）最大化。
氧氟沙星的PK参数与先前发表的其他患者群体的参数相当。较高的每日剂量可能为结核病治疗带来药效学优势。
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