海马体与言语及图像材料的记忆。
The hippocampus and memory of verbal and pictorial material.
作者信息
Papanicolaou Andrew C, Simos Panagiotis G, Castillo Eduardo M, Breier Joshua I, Katz Jeffrey S, Wright Anthony A
机构信息
Vivian L. Smith Center for Neurologic Research, Department of Neurosurgery, University of Texas Health Science Center-Houston, Texas 77030, USA.
出版信息
Learn Mem. 2002 May-Jun;9(3):99-104. doi: 10.1101/lm.44302.
Recognition of words and kaleidoscope pictures showed a double dissociation of left and right hippocampal activity using magnetic source imaging (MSI). MSI has advantages over alternative imaging techniques that measure hemodynamic changes for identifying regional changes in brain activity in real time and on an individual subject basis without the need for image subtraction. In this study, lists of words or kaleidoscope pictures were presented for memorization followed by tests of list items and foils during which brain activity was recorded. There was greater activation in the left than the right hippocampus with abstract nouns (e.g., relief) and greater activation in the right than the left hippocampus with kaleidoscope pictures. This dissociation was evident on a case by case basis. This study demonstrates the specialization of the two medial temporal lobe (MTL) regions, including the hippocampi, for mnemonic processing of verbal and pictorial items that are difficult to encode verbally.
使用磁源成像（MSI）技术发现，单词识别和万花筒图片识别显示出左右海马体活动的双重分离。与测量血液动力学变化的其他成像技术相比，MSI具有优势，它能够在个体受试者基础上实时识别大脑活动的区域变化，而无需进行图像相减。在本研究中，呈现单词列表或万花筒图片以供记忆，随后对列表项目和陪衬物进行测试，并在此期间记录大脑活动。对于抽象名词（如“宽慰”），左侧海马体的激活程度高于右侧；对于万花筒图片，右侧海马体的激活程度高于左侧。这种分离在逐个案例中都很明显。本研究证明了两个内侧颞叶（MTL）区域，包括海马体，在对难以用言语编码的言语和图像项目进行记忆处理方面的专门化。
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