Kennepohl S, Sziklas V, Garver K E, Wagner D D, Jones-Gotman M
Neuropsychology and Cognitive Neuroscience Unit, McGill University, Montreal, Quebec, Canada.
Neuroimage. 2007 Jul 1;36(3):969-78. doi: 10.1016/j.neuroimage.2007.03.049. Epub 2007 Apr 4.
The role of the medial temporal lobe in learning and memory has been well established in research on humans and other animals. In humans, clinical and neuroimaging studies typically suggest material-specific lateralization in which the left and right temporal lobes are associated with verbal and nonverbal memory, respectively. It is often assumed that the temporal lobes are functionally alike, differing only in terms of the content to be learned. Here we present data that challenge this notion, showing that the type of material used during a memory task can influence fMRI activation patterns beyond the expected left-verbal/right-nonverbal dichotomy. Our results also suggest some degree of functional asymmetry in the medial temporal lobe that is independent of material type, pointing to underlying processing differences between the left and right temporal lobes.
内侧颞叶在学习和记忆中的作用在对人类和其他动物的研究中已得到充分证实。在人类中，临床和神经影像学研究通常表明存在材料特异性的功能侧化，即左、右颞叶分别与言语记忆和非言语记忆相关。人们常常认为颞叶在功能上是相似的，只是在要学习的内容方面有所不同。在此，我们展示的数据对这一观点提出了挑战，表明记忆任务中使用的材料类型能够影响功能磁共振成像（fMRI）激活模式，超出了预期的左言语/右非言语二分法。我们的结果还表明内侧颞叶存在一定程度的功能不对称，且这种不对称与材料类型无关，这表明左、右颞叶在潜在加工过程中存在差异。
