以丙二醇为溶剂的氯霉素滴耳液的耳毒性。

Ototoxicity of chloramphenicol ear drops with propylene glycol as solvent.

作者信息

Morizono T, Johnstone B M

出版信息

Med J Aust. 1975 Oct 18;2(16):634-8.

PMID:1207541

Abstract

The ototoxicity of chloramphenicol ear drops was studied in guinea-pigs. The ear drops consisted of chloramphenicol sodium succinate in propylene glycol; hence the ototoxicity of each chemical was also studied. The diluted chemicals were instilled in the middle ear cavity; thus clinical conditions were simulated, and the cochlear microphonic responses from the electrode on the round window of the cochlea were monitored as an indication of the hair cell function. Our experiment revealed that propylene glycol at the concentration of 10% or more caused irreversible deafness. Chloramphenicol sodium succinate in a concentration of 5% or more in Ringer's solution also caused irreversible deafness. It is recommended that propylene glycol should not be used in the ear drops as a solvent of the drug. Chloramphenicol at higher concentrations is not recommended for use in the middle ear cavity.

摘要

在豚鼠身上研究了氯霉素耳液的耳毒性。该耳液由丙二醇中的琥珀氯霉素钠组成；因此，也对每种化学物质的耳毒性进行了研究。将稀释后的化学物质滴入中耳腔；从而模拟临床情况，并监测来自耳蜗圆窗电极的耳蜗微音器反应，以此作为毛细胞功能的指标。我们的实验表明，浓度为10%或更高的丙二醇会导致不可逆性耳聋。林格氏液中浓度为5%或更高的琥珀氯霉素钠也会导致不可逆性耳聋。建议不应将丙二醇用作耳液中药物的溶剂。不建议在中耳腔使用高浓度的氯霉素。