丙二醇对豚鼠的耳毒性潜力。
The ototoxic potential of propylene glycol in guinea pigs.
作者信息
Vernon J, Brummett R, Walsh T
出版信息
Arch Otolaryngol. 1978 Dec;104(12):726-9. doi: 10.1001/archotol.1978.00790120052008.
Abstract
Propylene glycol, previously indicated to be ototoxic and to produce "deafness," was studied in the middle ear space of guinea pigs. Ninety percent propylene glycol produced conductive middle ear problems, but there was no loss of hair cells above that found in normal untreated animals. Ten percent propylene glycol produced no negative effects in the middle ear or elsewhere. Topical ear drops containing high concentrations of propylene glycol are contraindicated in cases with perforation of the tympanic membrane.
摘要
曾被指出具有耳毒性并会导致“耳聋”的丙二醇，在豚鼠的中耳腔中进行了研究。90%的丙二醇会引发中耳传导性问题，但未发现毛细胞损失超过正常未处理动物。10%的丙二醇在中耳及其他部位未产生负面影响。鼓膜穿孔病例禁用含高浓度丙二醇的外用耳滴剂。
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