Pacheco N D, McConnell E, Beaudoin R L
Bull World Health Organ. 1979;57 Suppl 1(Suppl):159-63.
A rodent model of sporozoite immunization against malaria based on a single immunizing dose is described. The duration of protective immunity was measured as a function of dose, and the results suggest that the percentage of protection follows a bimodal distribution. The first peak occurs between days 7-12 after immunization, while the second peak occurs at approximately 28 days. Although the percentage of protection declines steadily after the second peak, some immunity was detectable as long as 140 days after immunization with the higher doses.
本文描述了一种基于单次免疫剂量的疟原虫子孢子免疫啮齿动物模型。通过测量保护免疫的持续时间与剂量的函数关系，结果表明保护率呈双峰分布。第一个峰值出现在免疫后7 - 12天之间，而第二个峰值出现在大约28天。尽管第二个峰值后保护率稳步下降，但使用较高剂量免疫后长达140天仍可检测到一些免疫力。
