Zheng Yujian, Wu Jiyao, Ng Jack C, Wang Guoquan, Lian Wu
College of Public Health, Xinjiang Medical University, Urumqi 830054, People's Republic of China.
Toxicol Lett. 2002 Jul 7;133(1):77-82. doi: 10.1016/s0378-4274(02)00082-6.
The absorption and excretion of fluoride and arsenic were measured in a group of healthy volunteers given drinking water with naturally high concentration of fluoride (F 2.3 mg/l)(,) or high concentration of arsenic (As 0.15 mg/l), or high concentrations of both fluoride and arsenic (F 2.25 mg/l, As 0.23 mg/l and F 4.05 mg/l, As 0.58 mg/l), respectively. The results indicated that, for arsenic, the absorption rate, the proportion of urinary excretion and the biological-half-life did not show statistically significant differences between drinking water containing high arsenic alone and drinking water containing different levels of high arsenic and fluoride. Excretion and retention of arsenic were positively correlated to the total arsenic intake. Similar results were observed for fluoride. This suggests that there are different metabolic processes for arsenic and fluoride in respect to absorption and excretion; and no joint action can be attributed by these two elements.
对一组健康志愿者进行了研究，分别给他们饮用天然氟浓度高（氟2.3毫克/升）、砷浓度高（砷0.15毫克/升）或氟和砷浓度都高（氟2.25毫克/升、砷0.23毫克/升以及氟4.05毫克/升、砷0.58毫克/升）的饮用水，测量其氟和砷的吸收与排泄情况。结果表明，对于砷而言，单独饮用高砷水与饮用不同水平高砷和氟的水相比，其吸收率、尿排泄比例及生物半衰期在统计学上无显著差异。砷的排泄和潴留与总砷摄入量呈正相关。氟也观察到类似结果。这表明，在吸收和排泄方面，砷和氟有不同的代谢过程；且这两种元素之间不存在联合作用。
