Varga T, Rákóczy I
Morphol Igazsagugyi Orv Sz. 1975 Oct;15(4):287-95.
Lesions caused by a single subtoxic dosis of diquat were studied in rats. After the administration of diquat on the first day it was revealed in highest concentration in the lung, but in two weeks no traces of the drug could be demonstrated. On the first and third day activity of peroxidase in the liver and the number of peroxisomes as well significantly increases. On the first day after the administration of diquat in the lung damage to the surfactanct and increase of the capillary permeability was observed. Later degenerative changes of the pneumocytes I and II type, focal haemorrhagic edema and presence of alveolar macrophages can be revealed. In two and in four weeks a slight pulmonary fibrosis remains to show the damage to the lung. In kidney tubular lesions of toxic origin, in the phase of the regeneration increase of the number of lyosomes could be revealed. On the basis of this study and the data of other authors the possible mechanism of the intoxication with diquat is discussed.
研究了大鼠单次亚中毒剂量敌草快造成的损伤。在第一天给予敌草快后，发现其在肺中的浓度最高，但两周后未检测到该药物的痕迹。在第一天和第三天，肝脏中过氧化物酶的活性以及过氧化物酶体的数量也显著增加。在给予敌草快后的第一天，观察到肺中表面活性剂受损且毛细血管通透性增加。随后可发现Ⅰ型和Ⅱ型肺细胞的退行性变化、局灶性出血性水肿以及肺泡巨噬细胞的存在。在两周和四周时，仍有轻微的肺纤维化显示肺部受损。在肾毒性起源的肾小管病变中，在再生阶段可发现溶酶体数量增加。基于本研究及其他作者的数据，讨论了敌草快中毒的可能机制。
