Takeda Naokazu
Department of Virology II, National Institute of Infectious Diseases.
Nihon Rinsho. 2002 Jun;60(6):1138-42.
Acute gastroenteritis due to Norwalk virus(NV), a member of the family Caliciviridae, is a common illness worldwide. NV is a human pathogen causing food-borne and water-borne diseases that occur in various epidemiological settings. The disease is mild and self-limiting and the symptomatic phase lasts 24 to 72 hours. Genetic analyses of the polymerase and the capsid protein indicate that NV is grouped into two clusters, genogroup I and genogroup II. The development of recombinant virus-like particles made a great impact on the development of diagnostic assays such as antigen ELISA and antibody ELISA. Strong control measures are needed to prevent oyster-related outbreaks.
由诺如病毒(NV)引起的急性肠胃炎是一种全球常见疾病,诺如病毒属于杯状病毒科。NV是一种人类病原体,可引发食源性和水源性疾病,在各种流行病学环境中均可发生。该疾病症状较轻,具有自限性,症状期持续24至72小时。对聚合酶和衣壳蛋白的基因分析表明,NV可分为两个群,即基因组I和基因组II。重组病毒样颗粒的研发对抗原ELISA和抗体ELISA等诊断检测方法的发展产生了重大影响。需要采取强有力的控制措施来预防与牡蛎相关的疫情爆发。