含1,2-和1,7-二碳-闭式-十二硼烷（12）的阳离子2,2':6',2''-三联吡啶铂（II）配合物的合成及DNA结合性质

Synthesis and DNA-binding properties of cationic 2,2':6',2' '-terpyridineplatinum(II) complexes containing 1,2- and 1,7-dicarba-closo-dodecaborane(12).

作者信息

Todd Jean A, Rendina Louis M

机构信息

Department of Chemistry, The University of Adelaide, Adelaide, South Australia 5005, Australia.

出版信息

Inorg Chem. 2002 Jul 1;41(13):3331-3. doi: 10.1021/ic025536v.

DOI:10.1021/ic025536v

PMID:12079447

Abstract

The first examples of DNA metallointercalators containing a dicarba-closo-dodecaborane(12) (carborane) moiety are presented. Treatment of the labile platinum(II) complex Pt(OTf)(terpy) (terpy = 2,2':6',2' '-terpyridine) with the 1,2-carborane monothiol derivatives 1-HS(CH(2))(n)-1,2-C(2)B(10)H(11) (n = 0, 1) or the novel 1,7-carborane ligand, 1-HSCH(2)-1,7-C(2)B(10)H(11), affords the stable, brightly colored species Pt(1-S(CH(2))(n)-1,Z-C(2)B(10)H(11))(terpy) (Z = 2, n = 0, 1; Z = 7, n = 1) in good yield and purity. Preliminary DNA-binding experiments with calf-thymus DNA indicate an intercalative interaction by the platinum(II) complexes at high r(f) values.

摘要

首次展示了含有二碳-闭式-十二硼烷（12）（碳硼烷）部分的DNA金属嵌入剂的实例。用1,2-碳硼烷单硫醇衍生物1-HS(CH₂)ₙ-1,2-C₂B₁₀H₁₁（n = 0, 1）或新型1,7-碳硼烷配体1-HSCH₂-1,7-C₂B₁₀H₁₁处理不稳定的铂（II）配合物[Pt(OTf)(terpy)]⁺（terpy = 2,2':6',2''-三联吡啶），以良好的产率和纯度得到稳定的、颜色鲜艳的物种[Pt(1-S(CH₂)ₙ-1,Z-C₂B₁₀H₁₁)(terpy)]⁺（Z = 2, n = 0, 1；Z = 7, n = 1）。用小牛胸腺DNA进行的初步DNA结合实验表明，在高r(f)值下，铂（II）配合物存在嵌入相互作用。