Sheikh Aziz, Hurwitz Brian, Sibbald Bonnie, Barnes Greta, Howe Maggie, Durham Stephen
Department of Primary Health Care & General Practice, Imperial College of Science, Technology & Medicine, London, UK.
BMC Fam Pract. 2002 Jun 18;3:12. doi: 10.1186/1471-2296-3-12.
The house dust mite is the most important environmental allergen implicated in the aetiology of childhood asthma in the UK. Dust mite barrier bedding is relatively inexpensive, convenient to use, and of proven effectiveness in reducing mattress house dust mite load, but no studies have evaluated its clinical effectiveness in the control of childhood asthma when dispensed in primary care. We therefore aimed to evaluate the effectiveness of house dust mite barrier bedding in children with asthma treated in primary care.
Pragmatic, randomised, double-blind, placebo controlled trial conducted in eight family practices in England. Forty-seven children aged 5 to 14 years with confirmed house dust mite sensitive asthma were randomised to receive six months treatment with either house dust mite barrier or placebo bedding. Peak expiratory flow was the main outcome measure of interest; secondary outcome measures included asthma symptom scores and asthma medication usage.
No difference was noted in mean monthly peak expiratory flow, asthma symptom score, medication usage or asthma consultations, between children who received active bedding and those who received placebo bedding.
Treating house dust mite sensitive asthmatic children in primary care with house dust mite barrier bedding for six months failed to improve peak expiratory flow. Results strongly suggest that the intervention made no impact upon other clinical features of asthma.
在英国，屋尘螨是儿童哮喘病因中最重要的环境过敏原。防螨屏障床上用品相对便宜，使用方便，且在减少床垫屋尘螨负荷方面已证实有效，但尚无研究评估其在初级保健机构发放时对控制儿童哮喘的临床效果。因此，我们旨在评估防螨屏障床上用品对在初级保健机构接受治疗的哮喘儿童的有效性。
在英国的八个家庭医疗诊所进行实用、随机、双盲、安慰剂对照试验。47名年龄在5至14岁之间确诊对屋尘螨敏感的哮喘儿童被随机分配接受为期六个月的防螨屏障床上用品或安慰剂床上用品治疗。呼气峰值流速是主要关注的结局指标；次要结局指标包括哮喘症状评分和哮喘药物使用情况。
接受活性床上用品治疗的儿童与接受安慰剂床上用品治疗的儿童在平均每月呼气峰值流速、哮喘症状评分、药物使用情况或哮喘会诊次数方面均未发现差异。
在初级保健机构中，用防螨屏障床上用品治疗屋尘螨敏感的哮喘儿童六个月未能改善呼气峰值流速。结果强烈表明该干预措施对哮喘的其他临床特征没有影响。
