Grimes Julia P, Gregory Patrice M, Noveck Helaine, Butler Mark S, Carson Jeffrey L
Division of General Internal Medicine, University of Medicine and Dentistry, Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA.
Am J Med. 2002 Jun 15;112(9):702-9. doi: 10.1016/s0002-9343(02)01119-1.
There is a perception that the standard of care is to repair hip fractures surgically within 24 hours of hospitalization. However, it is unclear whether this reduces mortality or morbidity.
We performed a retrospective study in consecutive hip fracture patients, aged 60 years or older, who underwent surgical repair. Patients with metastatic cancer, trauma, or a fracture occurring >48 hours before admission were excluded. The primary outcome was long-term (up to 18 years) mortality. Secondary outcomes included 30-day mortality and decubitus ulcers, serious bacterial infections, myocardial infarction, and thromboembolism. Analyses were adjusted for medical conditions; the comparison group comprised patients who underwent surgery for hip fracture repair within 24 to 48 hours because there were no patients with active medical problems who underwent surgery within 24 hours.
Of the 8383 patients, surgery was delayed for more than 24 hours in 2464 patients (29%) for medical reasons and in 1341 patients (16%) without active medical problems. Compared with those who underwent surgery 24 to 48 hours after admission to the hospital, patients who underwent surgery more than 96 hours after admission did not have increased long-term mortality (hazard ratio = 1.07; 95% confidence interval [CI]: 0.95 to 1.21), although the risk of decubitus ulcer was increased (odds ratio = 2.2; 95% CI: 1.6 to 3.1). There were no associations between time-to-surgery and the other secondary outcomes.
Time-to-surgery in hip fracture patients was not associated with short- or long-term mortality after adjusting for active medical problems. Other than increasing the risk of decubitus ulcer formation, waiting did not appear to affect patients' outcomes adversely.
人们认为,护理标准是在住院24小时内对髋部骨折进行手术修复。然而,目前尚不清楚这是否能降低死亡率或发病率。
我们对60岁及以上接受手术修复的连续性髋部骨折患者进行了一项回顾性研究。排除患有转移性癌症、创伤或入院前48小时以上发生骨折的患者。主要结局是长期(长达18年)死亡率。次要结局包括30天死亡率、褥疮、严重细菌感染、心肌梗死和血栓栓塞。分析针对医疗状况进行了调整;对照组包括在24至48小时内接受髋部骨折修复手术的患者,因为没有在24小时内接受手术的有活动性医疗问题的患者。
在8383例患者中,2464例(29%)因医疗原因手术延迟超过24小时,1341例(16%)没有活动性医疗问题。与入院后24至48小时接受手术的患者相比,入院后96小时以上接受手术的患者长期死亡率没有增加(风险比=1.07;95%置信区间[CI]:0.95至1.21),尽管褥疮风险增加(优势比=2.2;95%CI:1.6至3.1)。手术时间与其他次要结局之间没有关联。
在调整活动性医疗问题后,髋部骨折患者的手术时间与短期或长期死亡率无关。除了增加褥疮形成的风险外,等待似乎并未对患者的结局产生不利影响。