Hidalgo Alicia
Neurodevelopment Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.
Trends Neurosci. 2002 Jul;25(7):365-70. doi: 10.1016/s0166-2236(02)02186-0.
The non-autonomous control of cell survival has long been thought to be a mechanism of adjusting cell populations in the vertebrate nervous system, enabling connectivity and myelination to produce a functional brain. Despite cellular evidence that analogous mechanisms occur in invertebrates, scepticism has long reigned over whether they operate in model organisms such as Drosophila. This has led to speculation that there are inherent differences between the development and evolution of simple brains and the brains of vertebrates. The great paradox has, until recently, been the absence of molecular evidence of trophic factors in Drosophila. Recent data have finally shown that EGFR (epidermal-growth-factor receptor) ligands function in the Drosophila CNS to maintain glial survival. Trophic interactions are, thus, a general mechanism of nervous system development.
长期以来，人们一直认为细胞存活的非自主控制是脊椎动物神经系统中调节细胞数量的一种机制，它能使连接性和髓鞘形成产生一个功能正常的大脑。尽管有细胞层面的证据表明类似机制也存在于无脊椎动物中，但对于这些机制是否在果蝇等模式生物中起作用，人们长期以来一直持怀疑态度。这引发了一种推测，即简单大脑与脊椎动物大脑在发育和进化方面存在内在差异。直到最近，一个巨大的悖论一直是在果蝇中缺乏营养因子的分子证据。最新数据终于表明，表皮生长因子受体（EGFR）配体在果蝇中枢神经系统中发挥作用以维持神经胶质细胞的存活。因此，营养相互作用是神经系统发育的一种普遍机制。
