Avcin T, Cimaz R, Falcini F, Zulian F, Martini G, Simonini G, Porenta-Besic V, Cecchini G, Borghi M O, Meroni P L
Department of Paediatrics, University of Ljubljana, Slovenia, Italy.
Ann Rheum Dis. 2002 Jul;61(7):608-11. doi: 10.1136/ard.61.7.608.
Antibodies against cyclic citrullinated peptide (anti-CCP) are considered to be specific for rheumatoid arthritis (RA).
To assess the clinical significance of anti-CCP in a cohort of patients with juvenile idiopathic arthritis (JIA).
Anti-CCP were tested by an enzyme linked immunosorbent assay (ELISA) in serum samples from 109 patients with JIA (30 boys, 79 girls), with a mean age of 8.7 years (range 0.6-20.3) and mean disease duration of 3.6 years (range 3 months to 15.6 years). As control groups, anti-CCP were also tested in sera of 30 healthy children, 25 patients with juvenile onset systemic lupus erythematosus (SLE), and 50 adult patients (30 with RA, 20 with SLE).
Positive anti-CCP values were found in sera of two patients with JIA (2%), one with polyarthritis, and one with oligoarthritis. Statistical analysis showed that anti-CCP were not associated with the presence of antinuclear antibodies, raised erythrocyte sedimentation rate, or erosions. In the control groups, none of the patients with juvenile onset SLE and only one of 20 adults with SLE were positive for anti-CCP, but 19/30 (63%) adults with RA showed anti-CCP positivity.
Anti-CCP can be detected in children with JIA, but are less frequently present than in adults with RA.
抗环瓜氨酸肽抗体（抗CCP）被认为是类风湿关节炎（RA）的特异性抗体。
评估抗CCP在一组幼年特发性关节炎（JIA）患者中的临床意义。
采用酶联免疫吸附测定（ELISA）检测109例JIA患者（30例男孩，79例女孩）血清样本中的抗CCP，这些患者的平均年龄为8.7岁（范围0.6 - 20.3岁），平均病程为3.6年（范围3个月至15.6年）。作为对照组，还检测了30例健康儿童、25例幼年型系统性红斑狼疮（SLE）患者和50例成年患者（30例RA患者，20例SLE患者）血清中的抗CCP。
在2例JIA患者（2%）血清中发现抗CCP阳性，1例为多关节炎型，1例为少关节炎型。统计分析表明，抗CCP与抗核抗体的存在、红细胞沉降率升高或糜烂无关。在对照组中，幼年型SLE患者均无抗CCP阳性，但20例成年SLE患者中只有1例阳性，而30例成年RA患者中有19例（63%）抗CCP阳性。
JIA患儿可检测到抗CCP，但与成年RA患者相比，其出现频率较低。
