Division of Pediatric Rheumatology, Department of Pediatrics, and the Center for Immunology, University of Minnesota, Minneapolis, MN, United States.
Front Immunol. 2019 Jan 14;9:3168. doi: 10.3389/fimmu.2018.03168. eCollection 2018.
Autoantibody production occurs in juvenile idiopathic arthritis (JIA) and numerous other autoimmune diseases. In some conditions, the autoantibodies are clearly pathogenic, whereas in others the roles are less defined. Here we review various autoantibodies associated with JIA, with a particular focus on antinuclear antibodies and antibodies recognizing citrullinated self-antigens. We explore potential mechanisms that lead to the development of autoantibodies and the use of autoantibody testing in diagnosis and prognosis. Finally, we compare and contrast JIA-associated autoantibodies with those found in adults with rheumatoid arthritis (RA).
自身抗体的产生发生在幼年特发性关节炎（JIA）和许多其他自身免疫性疾病中。在某些情况下，自身抗体显然是致病的，而在其他情况下，其作用则不太明确。在这里，我们回顾了与 JIA 相关的各种自身抗体，特别关注抗核抗体和识别瓜氨酸化自身抗原的抗体。我们探讨了导致自身抗体产生的潜在机制，以及自身抗体检测在诊断和预后中的应用。最后，我们比较和对比了 JIA 相关的自身抗体与成年类风湿关节炎（RA）患者的自身抗体。
