Uza G, Crîsnic I
Pathol Eur. 1975;10(4):327-32.
Platelet adhesiveness increases significantly after angiotensin II administration, in pressor and subpressor doses, only in the hypertensive patients with urinary infection. The k index on the thrombelastogram decreases significantly following angiotensin II infusion in pressor doses both in the hypertensive patients with urinary infection and in those without urinary infection. At the same time, angiotensin II infusion in pressor and subpressor doses determines a significant increase of epsilon index in both hypertensive patients with urinary infection and in those without urinary infection. These results pose the problem of thrombocyte sensitization by the urinary infection to the vasopressor substance. The increased tendency to thrombosis by angiotensin, in hypertensive patients with urinary infection, could constitute a mechanism of malignant transformation of arterial hypertension.
仅在患有泌尿系统感染的高血压患者中，给予血管紧张素II后，无论是升压剂量还是亚升压剂量，血小板黏附性均显著增加。在患有泌尿系统感染和未患有泌尿系统感染的高血压患者中，给予升压剂量的血管紧张素II后，血栓弹力图上的k指数均显著降低。同时，给予升压和亚升压剂量的血管紧张素II后，患有泌尿系统感染和未患有泌尿系统感染的高血压患者的ε指数均显著增加。这些结果提出了泌尿系统感染使血小板对血管加压物质敏感的问题。在患有泌尿系统感染的高血压患者中，血管紧张素导致的血栓形成倾向增加，可能构成动脉高血压恶性转化的一种机制。
